GnRH-a对卵巢黄体期生殖激素水平及卵泡募集的影响

Effects of GnRH-a on Hormal Seceration and Follicle Development in Corpus Luteal Phase

目的:探讨黄体期垂体生理性抑制的情况下,应用GnRH-a后对于垂体和卵巢激素分泌水平及卵泡发育过程的影响。方法:选择体外受精(IVF)或单精子卵胞浆内注射(ICSI)治疗的不孕妇女,给予常规长方案促排卵,并随机分为短效达菲林组(14人)及长效达菲林组(6人),两组分别于黄体中期开始给予每日短效达菲林0.05mg皮下注射或长效达菲林1/3支(1.25mg)单次注射处理。测定患者注射0、2、4日(对应于排卵后第7、9、11日)以及下一月经周期第2日外周血促卵泡生成素(FSH)、促黄体生成素(LH)、雌激素(E2)及孕酮(P)水平。结果:两组FSH,LH水平在用药后第2天均达到最高值,随后呈现逐渐下降趋势,不同时间点间差异有显著性(P<0.01)。两组E2水平在用药后呈现逐渐下降的趋势,但是不同时间点间差异无显著性。短效达菲林组P水平用药前后无明显变化,长效达菲林组P水平在用药后呈现逐渐下降的趋势,但是各时间点无显著性差异。结论:自然周期黄体期或服用短效避孕药周期应用GnRH-a是否能使FSH及LH升调节,从而使得卵泡过早募集。

Objective： To determine the effect of GnRH-a on the hormal seceration and the follicle development in corpus luteal phase. Methods： The patients with infertility were divided into two groups and received controlled ovary stimulation with either short-ef- fect daphilil （0.05 mg qd） or long-effect daphilii （1.25 mg） randomizedly at the mid-luteal phase. The levels ofFSH/LH/E2 and P were detected after the injecti6n of GnRH-a at day 0/2/4 and the second day of the next menstrual cycle. Results： The level of FSH and LH reached the maximum at the second day of the treatment, and then decreased significantly. E2 level decreased after the treatment of GnRH-a but there is no significant difference. The level of P had no difference with the short-effect daphilil and decreased with the long-effect daphilil but had no statistically difference. Conclusions： GnRH-a can upregnlate the FSH and LH seceration so as to recruimt follicles earlier.