肝细胞生长因子拮抗剂NK4抑制肿瘤的研究进展

Progress in effects of NK4 inhibiting Tumor as hepatocyte growth factor antagonist

肝细胞生长因子(HGF)是一种多功能细胞因子,其生物学活性由c-Met蛋白所介导,通过多种途径调节细胞的生长,发挥重要的生理效应。Met活化失调在许多肿瘤的发生及侵袭中都有重要的作用。目前,对HGF/c-Met系统的研究已取得了很大进展。c-Met抑制剂成为抗肿瘤药物的研究热点,其中NK4能显著抑制肿瘤的生长、增殖和转移,本文对NK4在抗肿瘤方面的作用做一综述。

Hepatoeyte growth factor （HGF） is a multifunctional cytokine, whose biological activity is mediated by the c-Met pro- tein. It can regulate cell growth through a variety of ways and play an important physiological effect. The activation disorders have an im- portant role in the tumor incidence and invasion. Currently, a lot of work has been done on the HGF / c-Met system, and inhibitor of c-Met has become the hot spots as anti-cancer drugs, one of which NK4 could significantly inhibit tumor growth, proliferation and metastasis. This review will address the progress in the studies on the effects of NK4 on inhibiting tumor.