宫颈癌中相关基因启动子高甲基化研究进展

Progress of High Methylation On Cerical Cancer Related Gene Promoter

本文主要从分子水平介绍了在宫颈癌发生发展过程中抑癌基因的甲基化的作用。以往认为人乳头状病毒高危型的的感染是导致宫颈癌发生的主要因素。随着科技的发展,宫颈癌组织中抑癌基因的甲基化越来越备受关注。既往认为基因内突变和染色体物质缺失是肿瘤抑制基因失活的主要原因。但是,启动子CPG岛异常甲基化导致的基因失活在肿瘤发生发展过程中起着非常重要的作用现已确切证明,DNA甲基化是肿瘤抑制基因失活的第三种机制,而且在某些情况下是抑癌基因失活的惟一机制。对宫颈癌组织中的对相关抑癌基因甲基化的筛选并作为标记应用在检测宫颈癌中,这在防止宫颈癌的发生起到重大作用,还可有望作为宫颈癌治疗疗效检测的一项手段。

This paper introduces the molecular level in cervical cancer occurrence and development process of tumor suppressor genes methylation. It is said that HPV infection risk of cerical cancer is the main factor to occur. With the development of science and technology, cervical tissue tumor suppressor genes and the methylation get more and more attention. Always think gene mutations and lack substance in chromosome inactivation of tumor suppressor genes are the main reasons. However, the CPG promoter methylation cause abnormal island of gene inactivation in cancer development plays a very important role had proved conclusively, DNA methylation is the third for tumor suppressor genes deactivation mechanism, and in some cases are the only mechanism. The organization~ for cerical cancer to relevant tumor-suppressor gene screening of methylation and application in cancer detection as mark, which occurred in preventing cervical cancer, also can play an important role for cerical cancer to test a curative effect.