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MicroRNA在人类肿瘤中的角色及其应用 被引量：2

Role of microRNAs in human tumor and its applications
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摘要 微小RNA(microRNAs,miRNAs)是一类含有约22个核苷酸的内源性非编码RNAs,通过与靶基因mRNA的3′端非翻译区(3′untranslated region,3′UTR)不完全性互补配对,介导转录后基因调控。miRNAs在人类肿瘤的发生和发展中扮演重要角色,发挥着癌基因或抑癌基因的作用。miRNAs可以作为肿瘤的生物标记和诊断工具,将成为新一代的抗肿瘤治疗的靶点。 MicroRNAs （miRNAs） are endogenous noncoding RNAs, about 22 nucleotides in length, which mediate the post-transcriptional gene modulation by annealing to incomplete complementary sequences in the 3＇ untranslated regions of target mRNAs. MicroRNAs play important roles in the occur-rence and development of human tumor, and act as either tumor suppressors or oncogenes. They can be used as diagnostic markers of tumor and will become the new anti-cancer therapeutic targets in the future.
作者 柯慧 丁彦青 王爽
机构地区 南方医科大学病理教研室
出处 《国际病理科学与临床杂志》 CAS 2009年第3期225-230,共6页 Journal of International Pathology and Clinical Medicine
关键词 MICRORNA 肿瘤 诊断 治疗 microRNA tumor diagnosis therapy
分类号 R730.2 [医药卫生—肿瘤]
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参考文献36

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国际病理科学与临床杂志
2009年 第3期

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