摘要
p66Shc是调控氧化应激和生命周期的关键蛋白。在氧化应激信号的刺激下,p66Shc在线粒体内氧化细胞色素C产生大量活性氧,造成细胞的氧化损伤。最新的研究表明,p66Shc可能在衰老及衰老相关的疾病如糖尿病中扮演关键的角色。本文简要综述p66Shc的结构、功能、相关的信号通路及其在糖尿病领域的最新研究进展。
The p66Shc adaptor protein controls cellular oxidative stress responses and life span. It oxidizes cytochrome C and generates reactive oxygen species (ROS) within mitochondria in response to oxidative stress. Recently, there is growing evidence suggests that p66Shc is involved in aging and aging- related disease, such as diabetes mellitus. The present review will focus on our current knowledge of the structure and function of p66Shc, and its role in diabetes mellitus.
出处
《国际病理科学与临床杂志》
CAS
2009年第3期250-253,共4页
Journal of International Pathology and Clinical Medicine
关键词
P66SHC
氧化应激
活性氧
糖尿病
p66Shc
oxidative stress
reactive oxygen species
diabetes