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衔接蛋白p66Shc在糖尿病及其并发症中的作用 被引量：3

Role of adaptor protein p66Shc in diabetes and its complication
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摘要 p66Shc是调控氧化应激和生命周期的关键蛋白。在氧化应激信号的刺激下,p66Shc在线粒体内氧化细胞色素C产生大量活性氧,造成细胞的氧化损伤。最新的研究表明,p66Shc可能在衰老及衰老相关的疾病如糖尿病中扮演关键的角色。本文简要综述p66Shc的结构、功能、相关的信号通路及其在糖尿病领域的最新研究进展。 The p66Shc adaptor protein controls cellular oxidative stress responses and life span. It oxidizes cytochrome C and generates reactive oxygen species （ROS） within mitochondria in response to oxidative stress. Recently, there is growing evidence suggests that p66Shc is involved in aging and aging- related disease, such as diabetes mellitus. The present review will focus on our current knowledge of the structure and function of p66Shc, and its role in diabetes mellitus.
作者 聂静 孙林 刘伏友
机构地区 中南大学湘雅二医院肾脏病研究所
出处 《国际病理科学与临床杂志》 CAS 2009年第3期250-253,共4页 Journal of International Pathology and Clinical Medicine
关键词 P66SHC 氧化应激 活性氧 糖尿病 p66Shc oxidative stress reactive oxygen species diabetes
分类号 R587.2 [医药卫生—内分泌]
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参考文献30

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同被引文献35

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国际病理科学与临床杂志
2009年 第3期

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