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Rho相关激酶Rock在心血管疾病中的研究进展 被引量：8

Progress of Rho-associated coiled-coil protein kinase in cardiovascluar diseases
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摘要 Rho相关的卷曲蛋白激酶(Rho-associated coiled-coil protein kinase,ROCK)是新近发现的与细胞凋亡相关的激酶,在多种细胞中均有表达,ROCK参与调节细胞的多种行为与功能,包括收缩、游走黏附、增殖及调亡。研究表明ROCK与血管再狭窄、心肌损伤、心肌细胞凋亡及心力衰竭等有关联。 Rho-associated coiled-coil protein kinase （ROCK） is associated with apoptosis. ROCKs have been found to regulate a wide range of fundamental cell functions such as contraction, motili- ty,proliferation, and apoptosis. It has been shown that ROCK is associated with restenosis, myocardial damage, myocardial apoptosis, and heart failure.
作者 董家龙 李菊香 洪葵
机构地区 南昌大学第二附属医院心内科
出处 《国际病理科学与临床杂志》 CAS 2009年第3期263-266,共4页 Journal of International Pathology and Clinical Medicine
关键词 Rho相关激酶 ROCK 信号通路 心肌细胞 心血管疾病 Rho-associated coiled-coil protein kinase cell cardiovascular diseases signal transduction myocardial
分类号 R54 [医药卫生—心血管疾病]
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参考文献25

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  • 2Tanaka T,Nishimura D,Wu RC,et al.Nuclear Rho kinase,ROCK2 targets p300 acetyltransferase[J].J Biol Chem,2006,281(22):15320 -15329.
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同被引文献105

  • 1张云香,王家富.血管内皮细胞损伤与肿瘤坏死因子α的因果效应[J].中国临床康复,2005,9(27):123-125. 被引量：22
  • 2马小欣,赵慧颖,徐宝华.Rho/Rho激酶与动脉粥样硬化及冠心病的关系[J].中国微循环,2007,11(2):138-141. 被引量：9
  • 3Kim JS, Kim JG, Jeon CY, et al: Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in maerophages[J]. Exp Mol Med, 2005, 37(6):575-587.
  • 4Lcmaric A, Bourdonnay E, Morzadec C, ct al: Inorganic arsenic activates reduced NADPH oxidase in human primary macrophages through a Rho kinase/p38 kinase pathway [J]. J Immtmol, 2008, 180 (9):6010-6017.
  • 5Senokuchi T, Matsumura T, Sakai M, et al: Statins suppress oxidized low density lipoprotein-induced macrophage proliferation by inactivation of the small G 15rotein-p38 MAPK pathway [J]. J Biol Chem, 2005, 280(8):6627-6633.
  • 6Zhou S, Bachem MG,,Seufferlein T, et al: Low intensity pulsed ultra- sound accelerates macrophage phagocytosis by a pathway that requires actin polymerization, Rho, and Src/MAPKs activity [J]. Cell Signal, 2008, 20(4):695-704.
  • 7Lover FA, Gonzalez I, Salih DA, et al: Convergence of Igf2 expression and adhesion signalling via RhoA and p38 MAPK enhances myogenic differentiation[J]. J Cell Sci, 2006, 119(Pt 23):4828-4840.
  • 8Galaria, II, Fegley AJ, Nicholl SM, et al: Differential regulation of ERK1/2 and p38 (MAPK) by components of the Rho signaling pathway during sphingosine-1-phosphate-induced smooth muscle cell migration[J]. J Surg Res, 2004, 122(2):173-179.
  • 9Hart JS, Macarak E, Rosenbloom J, et al: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways[J]. Eur J Biochem, 2003, 270(16):3408-3421.
  • 10Dubroca C, You D, Levy BI, et al: Involvement of RhoA/Rho kinase pathway in myogenic tone in the rabbit facial vein [J]. Hypertension, 2005, 45(5):974-979.

引证文献8

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国际病理科学与临床杂志
2009年 第3期

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