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分子靶向药物用于晚期或复发子宫内膜癌的研究进展 被引量:3

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摘要 子宫内膜癌是女性生殖系统常见的恶性肿瘤,晚期或复发子宫内膜癌患者往往失去了手术时机,治疗较为棘手,以药物治疗为主,因此药物治疗受到广泛的关注和研究。分子靶向药物是近年新兴的抗肿瘤药物,在一些恶性肿瘤的防治中已经彰显成效。近年晚期或复发子宫内膜癌药物治疗的新策略转向应用针对肿瘤发展特异性生物环节的分子靶向药物,其中一些药物已进入临床研究阶段,并证实在延长患者生存期、缓解症状、提高生活质量及耐受性方面优于传统的化疗。现就分子靶向药物在晚期或复发子宫内膜癌中的应用进展作一综述。
作者 王娟 滕银成
出处 《现代妇产科进展》 CSCD 北大核心 2009年第7期548-550,共3页 Progress in Obstetrics and Gynecology
基金 上海市科委基金资助项目(No:07ZR14059)
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参考文献26

  • 1Doll A,Abal M,Rigau M,et al.Novel molecular profiles of endometrial cancer-new light through old windows[J].J Steroid Biochem Mol Biol,2008,108:221-229.
  • 2Leslie KK,Laidler L,Albitar L,et al.Tyrosine kinase inhibitors in endometrial cancer[J].Int J Gynecol Cancer,2005,15:409-411.
  • 3Ai ZH,Yin LH,Zhou XR,et al.Inhibition of survivin reduces cell proliferation and induces apoptosis in human endometrial cancer[J].Cancer,2006,107:746-756.
  • 4Zhao SJ,Chen X J,Lu X,et al.Epidermal growth factor signaling enhanced by long-term medroxyprogesterone acetate treatment in endometrial carcinoma[J].Gynecol Oncol,2007,105:45-54.
  • 5Magdrdena B,Andrzeg S,Tomasz R,et al.Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium[J].Oncology Rep,2007,18:261-265.
  • 6Albitar L,Pickett G,Morgan M,et al.Models representing type Ⅰ and type Ⅱ human endometrial cancers:Ishikawa H and Hec50co cells[J].Gynecol Oncol,2007,106:52-64.
  • 7Scaltriti M,Baselga J.The epidermal growthfactor receptor pathway:a model for targeted therapy[J].Clin Cancer Res,2006,12:5268-5272.
  • 8Albitar L,Carter MB,Davies S,et al.Consequences of the loss of p53,RB1,and PTEN:relationship to gefitinib resistance in endometrial cancer[J].Gynecol Oncol,2007,106:94-104.
  • 9Jasa KV,Fyles A,Elit L,et al.Phase Ⅱ study of erlotinib (OSI 774) in women with recurrent or metastatic endometrial cancer:NCIC CTG IND-148[J].Proc Am Soc Clin Oncol,2004,22:5019.
  • 10Oza AM,Eisenhauer EA,Elit L,et al.Phase Ⅱ study of erlotinib in recurrent or metastatic endometrial cancer:NCIC IND-148[J].J Clin Oncol,2008,26:4319-4325.

同被引文献39

  • 1黄晓东,易俊林,高黎,徐国镇,金晶,杨伟志,卢泰祥,吴少雄,吴仁瑞,胡伟汉,谢伟长,韩非,高远红,高剑铭,潘建基,陈传本,朗锦义,李涛,董昱,付玉彬,樊林,李柏森,黎静,王晓怀,陈炳旭,高献书,张萍,吴湘玮,胡炳强.抗表皮生长因子受体单克隆抗体h—R3联合放疗治疗晚期鼻咽癌的Ⅱ期临床研究[J].中华肿瘤杂志,2007,29(3):197-201. 被引量:100
  • 2Doll A, Abal M, Rigau M,et :al. Novel molecular profiles of endometrlal cancernew light through old windows [ J ]. J Steroid Biochem Mol Bioi ,2008,108:221-229.
  • 3Kaku T,Yoshikawa H,Tsuda H et al. Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women:central pathologic review and treatment outcome [ J ]. Cancer Lett, 2001, 167:39-48.
  • 4Dai D, Wolf DM, Litman ES, et al. Progesterone inhibits human endometrial cancer cell growth and invasiveness: down-regulation of cellular adhesion molecules through progesterone B receptors [ J ].Cancer Res, 2002,62 : 881 - 886.
  • 5Zhao SJ', Chen X,I, Lu X, et al. Epidermal growth factor signaling enhanced by long-term medroxyprogesterone acetate treatment in endometrial carcinoma [ J ]. Gynecol Oncol,2007 ,105 :45-54.
  • 6Leslie KK, Kumar NS, Richer J, et al. Differential expression of the A and B isoforms of progesterone receptor in human endometrial cancer cells. Only progesterone receptor B is induced by estrogen and associated with strong transcriptional activation [ J ]. Ann N Y Acad Sci ; 1997, 828 : 17-26.
  • 7Zhou YH, Tan F, Hess KR, et al. Tile expression of PAX6, PTEN, vascular endothelial growth factor, and epidermal growth factor receptor in gliomas: relationship to tumor grade and survival[ J ]. Clin Cancer Res, 2003,9: 3369-3375.
  • 8Goldman S, Shalev E. Difference in progesterone-receptor isoforms ratio between early and late first-trimester human trophoblast is lssociated with differential cell invasion and matrix metall ,roteinase 2 expression [ J]. Bio Reprod, 2006,74 : 13.
  • 9Barton J, Blaolodge G, Wakeling A. Growth factors and their receptors: new targets for prostate cancer therapy [ J ]. Urology, 2001,58 : 114-122.
  • 10Magdnlena B, Andrzeg S, Tomasz R, et al. Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium [ J ]. Oncol Rep, 2007,18 : 261-265.

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