Id-1在子宫内膜腺癌中的表达及与VEGF、TSP-1的关系

Expression of Id-1 in the Endometrial Adenocarcinoma and its Correlation with VEGF and TSP-1

目的探讨DNA结合抑制蛋白(Id-1)在子宫内膜腺癌组织中的表达以及与血管内皮生长因子(VEGF)、血小板反应素-1(TSP-1)的关系。方法免疫组织化学法检测56例子宫内膜腺癌、18例子宫内膜不典型增生、20例正常子宫内膜组织中Id-1及VEGF、TSP-1蛋白的表达;图像分析软件进行量化处理。结果子宫内膜癌组织中Id-1表达高于正常子宫内膜组织及子宫内膜不典型增生(P<0.05),且与组织分化程度及浸润肌层深度、手术病理分期有关(P<0.05)。子宫内膜癌组织中Id-1与VEGF表达呈正相关性(r=0.318,P=0.017),与TSP-1呈负相关(r=-0.453,P=0.000)。Id-1表达与生存时间无关(P>0.05)。结论Id-1在子宫内膜腺癌中存在着过表达;抑制TSP-1和促进VEGF可能是Id-1参与子宫内膜腺癌的发生发展的一个机制。

Objective To study the expressiort of inhibitors of DNA binding-1 （Id-1） in endometrial adenocarcinoma and its correlation with VEGF, TSP-1. Methods By using immunohistochemistry and image analysis, the expressions of Id-1, VEGF and TSP-1 proteins Were studied in a group of 56 patients with endometrial adenocarcinoma, 18 patients with atypia hyperplasia and 20 patients with normal endometria. Results The expression of Id-1 in endometrial adenocarcinoma tissues was significantly higher than that in normal endometria and atypia hyperplasia tissues（P〈0.05） and was significantly correlated with the histological grades, depth of myometrial invasion and clinical stage （all P〈0.05）. Id-1 expression in endometrial adenoearcinoma tissues was positively correlated with VEGF expression（r = 0.318, P=0.017）and negatively correlated with TSP-1 expression（r=-0. 453, P=0. 000）. No signifi- cant association was found between Id-1 expression and patients＇ survival time. Conclusions Overexpression of Id-1 is common in endometrial adenocarcinoma. Id-1 might be related to the carcinogenesis and progression of endometrial adenocarcinoma by decreasing TSP-1 expression and increasing VEGF expression.