非小细胞肺癌患者血清TPS水平及其临床价值研究

The levels and clinical significance of tissue polypeptide specific antigen(TPS) in serum of patients with non-small cell lung cancer(NSCLC)

目的:探讨血清TPS(组织多肽特异性抗原)水平与非小细胞肺癌(NSCLC)患者生物学特征的相关性及其临床应用价值。方法:采用ELISA法测定127例NSCLC患者和31例肺部良性肿瘤患者血清TPS水平,并以22例正常人血清作为对照。结果:NSCLC患者血清TPS水平高达377.2±302.5U/L,肺部良性肿瘤患者和正常对照组分别为109.7±51.9U/L和71.6±33.8U/L,NSCLC患者明显高于肺部良性肿瘤患者和正常对照组(P<0.001),取正常值为148U/L时,TPS对NSCLC诊断灵敏度是85%,特异度为84.9%;不同性别、年龄、病理类型之间和有无纵隔淋巴结转移NSCLC患者之间血清TPS水平接近,统计分析均无显著性差异(P>0.05)。TNM分期Ⅲ-Ⅳ期的病人血清TPS水平高达487.4±419.8U/L,明显高于Ⅰ-Ⅱ期病人(268.9±201.6U/L);手术前患者(386.3±317.5U/L)高于手术后(198.5±113.6U/L)患者;复发后病人(552.3±471.6U/L)明显高于复发前患者(204.2±133.7U/L);存活期3年以上病人(266.3±242.2U/L)明显低于存活期3年以内病人(489.5±353.3U/L),统计分析各组均有非常显著性差异(P<0.001)。结论:血清TPS水平与肿瘤活动度密切相关,能够反映疾病的严重程度,也可用于判定手术效果、监测复发和评估预后等。

Objective：To investigate the levels and clinical value of tissue polypeptide specific antigen （TPS） in serum of patients with non - small cell lung cancer（NSCLC）. Methods： TPS levels of 127 cases of NSCLC, 31 cases of lung benign tumor（LBT） and 22 cases of healthy control were measured by enzyme linked immunosorbent assay （ELISA）. Results：The serum TPS levels of NSCLC, LBT and healthy control were 377.2 ±302.5U/L, 109.7 ± 51.9 U/L and 71.6 ± 33. 8 U/L respectively. The levels of NSCLC group were significantly higher than those of LBT and healthy control groups （P 〈 0. 001 ） ,when the Cut -off value was 148 U/L, the sensitivity and specificity of NSCLC diagnosis were 85% and 84.9% respectively. The levels of TPS in serum were analogous between different gender, age and pathological type group and there were no significant difference（ P 〉 0.05 ）. The serum TPS levels of TNM Ⅲ-Ⅳ stage NSCLC patients（487.4 ±419.8U/L）, before operation patients（386.3 ± 317.5 U/L）, recrudescent patients （552.3 ±471.6 U/L） and survival below 3 years patients（489.5 ± 353.3U/L） were relatively higher than that in the Ⅰ-Ⅱ stage, after operation, no recrudescent and survival over 3 years patients. There were significant difference （ P 〈 0.001 ）. Conclusion ： TPS level in serum is closely related to tumor activity and reflects the severity of the disease, can also be used to determine effects of surgery, monitoring recurrence and evaluation of prognosis.