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人乳头状瘤病毒16,18型感染及MCM蛋白表达调控与人乳腺癌 被引量：1

HPV16,18 types infection and MCM7 protein expression regulation and human breast cancer
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摘要 高危型人乳头状瘤病毒16、18型E6、E7蛋白导致p53、Rb抑癌基因功能的失活以及E6、E7可分别直接或间接调控细胞周期DNA复制起始调节准许因子—微小染色体维持蛋白7的异常表达从而导致细胞周期复制异常涉及了HPV16型和HPV18型感染后人乳腺癌的发生、发展过程,本文就其相关机制及临床意义作一综述。 E6, E7 proteins of high risk human papillomavirus 16 and 18 types inducing inactivation of function of p53, Rb and aberrant expression of the minichromosome maintenance protein （MCMp） 7 of cell cycle replication licensing system may play an important role in the pathogenesis and development of human breast cancer. This review mainly summarized the related mechanism and clinical significance.
作者 任占平
机构地区 广西柳州市人民医院病理科
出处 《现代肿瘤医学》 CAS 2009年第7期1368-1371,共4页 Journal of Modern Oncology
基金 广西卫生厅医疗卫生科研课题项目(编号:Z2004094)
关键词 人乳头状瘤病毒 乳腺癌 微小染色体维持蛋白 抑癌基因 human papillomavirus breast neoplasms MCM Tumor suppressor gene
分类号 R737.9 [医药卫生—肿瘤]
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参考文献22

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二级参考文献10

  • 1任占平.微小染色体维持蛋白与肿瘤[J].诊断病理学杂志,2004,11(6):427-429. 被引量：12
  • 2赵富玺,穆雅琴,郭俊成,刘润花.Bcl-2 Survivin CD44v6的表达HPV_(16/18)感染及其与宫颈癌发生的相关性探讨[J].中国肿瘤临床,2007,34(8):426-429. 被引量：2
  • 3Seewaldt VL, Mrozek K, Dietze EC, et al. Human papillomavirus type 16 E6 inactivation of p53 in normal human mammary epithelial cells promotes tamoxifen-mediated apoptosis [J]. Cancer Res, 2001, 61(2): 616-624.
  • 4Murphy N, Ring M, Heffron CC, et al. p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer[J].J Clin Pathol, 2005, 58(5): 525-534.
  • 5Sterner JM, Dew-Knight S, Musahl C, et al. Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7[J]. Mol Cell Biol, 1998, 18(5): 2748-2757.
  • 6Lawson JS, Tran D, Rawlinson WD. From Bittner to Barr: a viral, diet and hormone breast cancer aetiology hypothesis[J]. Breast Cancer Res, 2001, 3(2):81-85.
  • 7Bukholm IR, Bukholm G, Holm R, et al. Association between histology grade, expression of HsMCM2, and cyclin A in human invasive breast carcinomas[J].J Clin Pathol, 2003, 56(5): 368-373.
  • 8Calaf GM, Roy D. Gene and protein expressions induced by 17 beta-estradiol and parathion in cultured breast epithelial cells [J]. Mol Med, 2007,13(5-6):255-265.
  • 9Lei M. The MCM complex: its role in DNA replication and implications for cancer therapy[J]. Curr Cancer Drug Targets, 2005, 5(5): 365-380.
  • 10任占平,黄健辉,石喆,杜娟,陈蔚麟,戴文斌,唐德艳.引物介导原位标记技术检测乳腺癌组织中HPV16和18型感染[J].中国肿瘤临床,2003,30(4):243-246. 被引量：4

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现代肿瘤医学
2009年 第7期

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