血清CA125、CA15.3、CA242联合检测对乳腺癌诊断的价值

Combined Detection of Serum CA125, CA15.3, and CA242 for the Diagnosis of Breast Cancer

目的评价血清标志物糖类抗原125(CA125)、15.3(CA15.3)、242(CA242)联合检测对乳腺癌诊断的价值。方法对长海医院肿瘤科2003年9月至2005年9月期间收治的73例乳腺癌患者及60例健康人血清进行CA125、CA15.3、CA242检测。结果乳腺癌组三种肿瘤标志物检测的阳性率显著高于对照组(χ2检验,P<0.01)。乳腺癌组CA125、CA15.3、CA242及联合检测的阳性率由高到低依次为联合检测(68.49%)、CA15.3(49.32%)、CA125(34.25%)、CA242(28.77%),CA15.3阳性率与三种标志物联合检测的阳性率差异有统计学意义(χ2=5.546,P<0.05),即联合检测的阳性率高于CA15.3单独检测的阳性率。结论CA125、CA15.3、CA242联合检测能明显提高乳腺癌的检出率。

Objective To evaluate the combined detection of serum carbohydrate antigen 125 （CA125）, carbohydrate antigen 15.3 （CA15.3）, carbohydrate antigen 242 （CA242） for the diagnosis of breast cancer. Method 73 treated patients with breast cancer and 60 cases of healthy people were tested for serum levels of CA125, CA15.3, and CA242 in the Department of Oncology of Changhai Hospital from September 2003 to September 2005. Result The positive rate of the three tumor markers of the breast cancer patients was significantly higher than that of the healthy people （P〈0.01）. In the breast cancer group, the positive rates of combined detection of the three markers, CA15.3, CA125 and CA242 were 68.49%, 49.32%, 34.25% and 28.77%, respectively. CA15.3 positive rate is significantly lower from that of combined three markers （Х^2=5.546,P〈0.05）. Conclusion The combined detection of CA125, CA15.3, CA242 could significantly increase the detection rate of breast cancer.