老年人戊肝临床特点分析

Analysis of Clinical Characteristic of Viral Hepatitis E in the Elderly

目的探讨老年人戊型病毒性肝炎(戊肝)的临床特点。方法对老年人戊肝60例及非老年人戊肝64例作对照分析,比较两组之间的临床特点。结果老年戊肝患者组急性黄疸型比率和重型肝炎发病率,重叠感染率,合并基础疾病率,病死率,病程,胆红素水平,并发症(感染,腹水及感性脑病)的发生率均明显高于非老年组;而ALT,胆固醇,白蛋白及凝血酶原活动度要低于非老年组。两组在性别及临床表现上无明显差异。结论老年人戊肝不少见,病程长,病情重,预后不佳。

Objective To study the clinic features of the elderly with HEV infection. Method Patients with HEV infection were subclassified into two groups： the aged （age〉60 years, 60 cases） and the non-aged （age 13- 51, 63 cases）, which were studied retrospectively. Result Of the aged group, the percentage of acute hepatitis with jaundice, the occurrence of the fulminate hepatitis, the percentage of having other disease, mortality, course of disease, the level of bilirubin （TBIL） and complication （with infection, ascites and appearance of hepatic encephalopathy） were significantly higher than those of non-aged group. Meanwhile,with the increase in age,the levels of alanine transaminase （ALT）,cholesterol （CHO）, albumin （ALB） and the activity of proserpozyn （PTA） were gradually decreased.However,there was no significant difference in gender and symptoms. Conclusion With a high incidence, the aged patients has longer course of disease, severe illness and bad prognosis.