肾移植术后钙调神经素抑制剂的减量和免除

Minimization or Avoidance of Calcineurin Inhibitors after Renal Transplantation

钙调神经素抑制剂(CNI)在肾移植抗排异反应治疗中发挥重要作用,但其肾毒性被认为影响移植肾的长期存活。一些CNI节减方案(如CNI免用或减量)的应用显示其结果与标准剂量CNI方案相当,关于平衡CNI效用与毒性的研究仍在继续中。

Caleineurin inhibitors （CNIs） are playing an important role in preventing acute rejection in renal transplantation; however, their nephrotoxicity may impact long-term renal allograft survival. Several CNI-sparing regimens （such as CNI-avoidance or CNI-minimization） have shown at least comparable efficacy with standard-dose CNI regimens. Research continues to achieve the ＂best＂ balance between efficacy and toxieity of available immunosuppressive regimens.