^(18)F标记脱氧葡萄糖正电子发射断层显像/计算机断层成像中棕色脂肪摄取的规律和特点

Patterns and Characteristics of Brown Adipose Tissue Uptake of ^(18)F-FDG Positron Emission Tomograph/Computed Tomography Imaging

目的明确18F标记脱氧葡萄糖(18F-FDG)正电子发射断层显像(PET)/计算机断层成像(CT)中棕色脂肪(BAT)摄取的规律和特点。方法回顾性分析了2008年7月～2009年2月在北京协和医院行PET/CT躯干显像的1080例次患者的图像。结果共41例次(3.8%)有不同程度BAT摄取:主要在寒冷季节出现;常对称累及肩颈部和脊柱两侧,纵隔和腹部摄取常伴有体表摄取;女性比例高于男性(P=0.0030);平均年龄(P=0.0001)和体重指数(P=0.0415)明显低于无BAT摄取者;3例患者在休息和保暖3～7d后行二次显像,BAT摄取明显减少。结论BAT摄取具有一定发生规律和特征表现,休息和保暖可减少其摄取。

Objective To characterize the brown adipose tissue （BAT） uptake of ^18F-FDG on positron emission tomography （PET） /computed tomography （CT） imaging. Methods We retrospectively analyzed the clinical data of 1 080 patients who received all whole-body PET/CT studies in Peking Union Medical College Hospital from July 2008 to February 2009. Results Forty-one patients （3.8%） were identified to be with BAT uptake, especially during cold seasons. BAT uptake was mostly observed at the neck regions symmetrically （ n = 39）, and was also seen at paravertebral junctions （ n = 30） , perinephric regions （ n = 21 ） , and mediastinum （n = 10）. Patients with BAT uptake had significantly lower male/female ratio （P = 0. 0030）, younger age （P =0. 0001 ）, and less body mass index （BMI） （P =0. 0415）. Three patients with high BAT uptake underwent repeat PET/CT scans 3-7 days later. By keeping warm and full relaxation, BAT uptake disappeared in 2 cases and dramatically decreased in the other case. Conclusions BAT uptake commonly occurs during cold seasons in Beijing, especially in young females with low BMI. It usually has specific patterns, and can be avoided or remarkably reduced by asking the patients keep warm and full relaxation a few days before the scanning.