趋化因子在乳腺癌转移复发中作用的研究

Role of Chemokines in Metastasis and Relapse of Breast Cancer

趋化因子（chemokines）及其受体在乳腺癌中发挥着广泛而重要的作用，然而其调控机理仍不清楚。我们设想，趋化因子及其受体所构成的网络在机体内可能受神经、激素、细胞因子、酶及结合蛋白等的综合调节。Duffy抗原趋化因子受体（Duffy antigen receptor for chemokinesJDARC）、D6和CCX-CKR（Chemo Centryx chemokine receptor）等不下传信号的趋化因子结合蛋白（non-signaling chemokine binding protein）存在的事实表明体内的确存在趋化因子的转录后调节机制。这些趋化因子结合蛋白也被称为非典型性趋化因子结合物（atypical chemokine binder）、趋化因子诱饵受体（decoy receptor）、沉默受体（silent receptor）、清除槽（sink）、

Objective： Chemokine network consists of nearly 50 chemokines, about 20 chemokine receptors, and at least 3 atypical chemokine binders （ACB）. qqae expression and role of Duff）, antigen receptor for chemokine （DARC）, D6 and ChemoCentryx chemokine receptor （CCX-CKR） in breast cancer have already been studied independently in the past several years. However, the relationship and importance of these ACB are still unclear. In this study, we invastigated the characteristics of multiple ACB simultaneously.