Metastasis Is Cell Motility Disease

Multidisciplinary approach (surgery, chemotherapy and radiation) for the primary site of cancer is now almost established, however, recurrence, invasion and metastasis are still life threatening, thus the effort of fighting

Multidisciplinary approach （surgery, chemotherapy and radiation） for the primary site of cancer is now almost established, however, recurrence, invasion and metastasis are still life threatening, thus the effort of fighting against metastasis is critical and crucial. Cancer metastasis consists of sequential multiple steps including detach from the primary site, intravasation into the blood vessel, survival in the blood stream as circulating tumor cells, adhere to the endothelium, extravasation to the target tissue, homing and colonizing in the target organs. Cell migration is biologically pivotal for these several processes. Great improvement to understand the mechanism of invasion/metastasis was achieved along with the progress of cancer biology in this decade, however, most of the clinical trials targeted to the metastasis were dropped, and only few are successful, thus molecular target therapy oriented cancer invasion and metastasis has just begun.