Down-regulation and It's Molecular Biology of Nm-23H1 gene Transfection on Ras-to-MAPK Signal Transduction Pathway in Human High-metastatic Large Cell Lung Cancer Cell Line L9981

Backgroud and Objective Tumor metastasis is not only the malignant marker and characteristics of lung cancer, but also the key cause of failure to cure and lose their life of the patients

Backgroud and Objective Tumor metastasis is not only the malignant marker and characteristics of lung cancer, but also the key cause of failure to cure and lose their life of the patients with lung cancer. Illuminating the molecular mechanism of tumor invasion, metastasis and signal transduction related to tumor metastasis will provide a new targeting molecules and pathway for reversion of lung cancer and developing anticancer metastastic targeting drugs. It was well known that nm23-H1 gene was a tumor metastasis suppressor gene, and the abnormality of its structure and function was closely related to the invasive and metastatic ability of lung cancer. It has been proved that low expression and hetero-deletion in nm23- H1 gene was closely related to the high metastatic ability and poor prognosis for patient with lung cancer. Lung cancer combined with nm23-H1 gene deletion always has abnormal expression of some metastatic relative gene. Therefore, Zhou QjngHua hypothesize that nm23-H1 may be an upstream regulatory gene of metastasis-relating genes and control downstream regulatory genes to inhibit tumor metastasis .