The Difference of Gene Expression Prof ile in Human Large Cell Lung Cancer Cell Lines with Different Metastatic Potential

Background and Objective Lung cancer is the most lethal malignangy that threatens human heath and lives nowadays in the world, and meanwhile is also the one with worst

Background and Objective Lung cancer is the most lethal malignangy that threatens human heath and lives nowadays in the world, and meanwhile is also the one with worst clinical outcome. Invasion and metastasis of lung cancer is the leading cause of treatment failure and patients＇ deaths. Therefore the study of the molecular mechanisms of tumor invasion and metastasis has an important theoretical meaning and clinical application prospect. Invasion and metastasis of lung cancer is a complicated procedure with. interactions among tumor cells, human body and target tissues ,which is controlled by multiple genes and takes multiple steps to develop. A series of tumor associated genes and signal transduction pathways are also involved in this procedure. As for this large number of genes, traditional approaches such as Southern blot, North blot and RT-PCR have their limitations that can only study one or few genes and the simple interactions among them,