Comparative Proteomics Study on Human High-metastatic Large Cell Lung Cancer Cell Lines Before and After Transfecting with Nm23-H1 Gene

Background and Objective Lung cancer is not only the most dangerous threating tumor to human’s health and life, but also a malignant tumor with poor prognosis. In the past 10 years,

Background and Objective Lung cancer is not only the most dangerous threating tumor to human＇s health and life, but also a malignant tumor with poor prognosis. In the past 10 years, progress has been made about the basic and clinical study of lung cancer, but it is pity that there is no distinctly improvement in cure rate of lung cancer. The reasons were, on the one hand, that there was no means to early diagnosis in deed, so most patients were in late stage when they came to see doctor, and then lost the chance of surgical resection; on the other hand, human have few countermeasures to high-metastatic lung cancer. Metastasis is not only the malignant characteristics of lung cancer, but also the chief cause of failure to cure the disease and of high mortality. It has been well-known that lung cancer metastasis is a complex process involving multiple gene and steps. Controling the invasion and metastasis of lung cancer is the important measure to improve prognosis and life quality, and to increase survival rate. Some study have shown that there are two kinds of genes involved in influencing the metastasis of lung cancer, one is tumor metastatic accelerating genes, the other is tumor metastatic suppressive genes. R was actually the broken of the balance of the two kinds of genes that induced lung cancer metastasis. Furthermore, studies have shown that some genes may as upper stream controller and play a key role in lung cancer metastasis, and nm23-H1 gene may be one of such genes.