Investigation of the Relationship Between Tyrosine Kinase Receptor Family and AcquiredResistance of Lung Adenocarcinoma to Gef itinib

Background and Objective Lung cancer is one of the leading causes of cancer-related mortality in the world. Non-small-cell lung cancer (NSCLC) accounts for approximately 80%

Background and Objective Lung cancer is one of the leading causes of cancer-related mortality in the world. Non-smallcell lung cancer （NSCLC） accounts for approximately 80% of all cases of lung cancers patients. Chemotherapy has been an important role in the treatment of patients with NSCLC for over 30 years. However, most of treatment outcomes for NSCLC patients are far from satisfaction. Overexpression of epidermal growth factor receptor （EGFR） and constant activation of the gene by some type of mutations were found in 60% of NSCLC. Abnormal expression and activation of EGFR generally indicate poor prognosis. EGFR signaling pathway contributes to a number of cancer related events such as proliferation, apoptosis, angiogenesis and metastasis. The target therapy aimed at blocking EGFR signaling pathway is attractive. Get3tinib （ZD1839.