醒脑静对弥漫性轴索损伤脑磁共振弥散张量回复作用的临床评价

Evaluation of Xingnaojing injection in treatment of diffuse axonal injury with MRI diffuse tensor image

目的探讨醒脑静对弥漫性轴索损伤（DAI）患者的治疗和其脑磁共振弥散张量的回复作用。方法对30例采用醒脑静治疗的DAI患者（治疗组）和28例常规治疗的DAI患者（对照组），在治疗初始、治疗后第10、30、60天进行磁共振弥散张量检查，同步记录并比较治疗初始、治疗后第10天的格拉斯哥昏迷评分（GCS评分）和第30、60天的格拉斯哥结果评分（GOS评分）。比较两组的部分各向异性值（FA值）。结果治疗后第30天，治疗组较对照组GOS评分和FA值均升高。治疗后第60天，治疗组FA值仍较对照组升高，而GOS评分无明显差别。结论醒脑静能提高DAI患者的GOS评分，促进其脑磁共振弥散张量的回复。

Objective To evaluate Xingnaojing injection in treatment of diffuse axonal injury （DAI） with MRI diffuse tensor image （DTI）. Methods Thirty DAI patients were treated with Xingnaojing injection （trial group） and another 28 DAI patients were treated with routine medication （control group）. MRI DTI examinations were performed in both groups before and 10,30,60 d after treatments, meanwhile, the Glasgow coma scale （GCS） scores were also recorded. The fractional anisotropy （FA） values of DTI were compared between two groups. Results FA values and GCS scores of trial group were higher than those of control group 30 d after treatments; the FA values of trial group were still higher than those of control group 60 d after treatments, however, there were no differences between two groups in GCS scores. Conclusion Xingnaojing injection can improve GCS score and FA value of MRI DTI of DAI patients.