膈下逐瘀汤加味治疗慢性萎缩性胃炎癌前病变28例临床观察

Therapeutic Effect of Modified Gexia Zhuyu Decoction for the Treatment of Precancerous Lesion of Chronic Atrophic Gastritis:An Observation of 28 Cases

目的:观察膈下逐瘀汤加味治疗慢性萎缩性胃炎癌前病变的临床疗效。方法:将44例患者随机分为2组。治疗组28例用膈下逐瘀汤加味辨证治疗,对照组16例予胃复春治疗。观察2组临床疗效。结果:临床总有效率治疗组为85.7%,对照组为56.3%,2组比较,差异有显著性意义(P<0.05)。胃镜及病理组织学总有效率治疗组为82.1%,对照组为50.0%,2组比较,差异有显著性意义(P<0.05)。结论:膈下逐瘀汤加味治疗慢性萎缩性胃炎癌前病变,对临床症状的缓解和胃黏膜癌前病变的病理改善疗效满意。

Objective:To observe the therapeutic effect of Modified Gexia Zhuyu Decoction (MGZD) for the treatment of precancerous lesion of chronic atrophic gastritis.Methods:Forty-four qualified patients were randomized into 2 groups:the treatment group(n=28) received MGZD based on syndrome differentiation,and the control group(n=16) received Weifuchun.The therapeutic effect was evaluated after treatment Results:The total therapeutic effective rate was 85.7%in the treatment group,and 56.3%in the control group,the difference being significant between the two groups(P<0.05).The total gastroscopic and histopathological effective rate was 82.1%in the treatment group and 50.0%in the control group,the difference being significant between the two groups(P<0.05).Conclusion:MGZD shows certain effect on relieving clinical symptoms and gastric mucosal precancerous lesion in patients with precancerous lesion of chronic atrophic gastritis.