成人非酒精性脂肪性肝病与代谢综合征关系

Relationship between nonalcoholic fatty liver disease and metabolic syndrome in adults

目的研究成人非酒精性脂肪性肝病(NAFLD)与代谢综合征(MS)的关系。方法以175例NAFLD患者为病例组,54名非脂肪性肝病体检者为对照组,检测2组的收缩压(SBP)、舒张压(DBP)、腰围(WI)、甘油三酯(TG)、空腹血糖(FBG)、高密度脂蛋白胆固醇(HDL-C)。结果病例组WI、SBP、TG、FBG等指标均高于对照组(分别t=3.790,3.688,2.825,3.251,3.429,2.635,均P<0.01);HDL-C低于对照组(t=2.849,P<0.01);中心性肥胖、高血压、高TG血症、低HDL-C血症、高血糖及MS的患病率高于对照组(分别χ2=29.02,8.64,11.37,6.51,11.72,9.65,均P<0.01),合并MS组分≥3项者的比例高于对照组(χ2=6.15,P<0.05),合并MS组分≤1项者的比例低于对照组(χ2=26.29,P<0.01)。结论NAFLD是MS的组成成分之一,NAFLD可用于预测代谢紊乱危险因素的聚集。

Objective To study the relationship between nonalcoholic fatty liver disease（NAFLD） and metabolic syndrome（MS） in adults. Methods Overall 175 NAFLD patients and 54 non-fatty liver adults were assigned as survey group and contrast group. The levels of systolic blood pressure （ SBP）, diastolic blood pressure （DBP）, waistline （WI）, triglyceride （TG） ,fasting blood glucose（FBG） ,high density lipoprotein cholesterol（HDL-C） were tested and analyzed. Results The levels of SBP, DBP, WI, TG, FBG in survey group were significantly higher than those in contrast group（ t = 3. 790,3. 688, 2. 825,3.251,3. 429,2. 635 ,P 〈 0. 01 ）. The level of HDL-C in survey group was significantly lower than that of in contrast group （ t = 2. 849, P 〈 0. 01 ）. Central obesity, high blood pressure, high blood triglyceride, low high density lipoprotein and hyperglycemia in survey group were significantly higher than those in contrast group（χ2 =29. 02,8. 64,11.37,6. 51,11.72, 9.65, P 〈 0. 01 ）. The proportion of the patients with three or more than three components of MS in survey group was significantly higher than that of in contrast group （χ2 = 6. 15, P 〈 0. 05 ）. And the proportion of the patients with one or without component of MS in survey group was significantly lower than that of in contrast group（χ2 = 26. 29, P 〈 0. 01 ）. Conelusion NAFLD is a component of MS. NAFLD could be a predictor for metabolic disorder.