高尿酸血症与瘦素的相关性分析

The relationship between hyperuricemia and Leptin

目的:探讨瘦素(Leptin)水平与高尿酸血症相关关系。方法:从2007年1～7月新疆医科大学附属中医医院住院病人中筛选出400例为研究对象,其中高尿酸血症组190例,正常组为同期该院的无高尿酸血症及痛风、无血缘关系及年龄性别构成无差别者210例。分别检测一般身体指标及生化指标。通过现场问卷完成研究对象的一般情况、疾病史的调查,采用ELISA酶联免疫法检测血清Leptin水平。结果:高尿酸血症组血清尿酸(SUA),甘油三酯(TG),高密度脂蛋白(HDL-C)及体重、体质指数(BMI)与正常组相比差异均有统计学意义,其中除HDL-C外均为高尿酸血症组高于正常组(P<0.05),Leptin与收缩压(SBP)、舒张压(DBP)、BMI、SUA均呈正相关。结论:Leptin参与代谢紊乱的病理机制,与代谢综合征指标密切相关,可能是高尿酸血症、肥胖、血脂异常等代谢综合征的共同发病基础。

Objectives： To study the relationship between hyperuricemia and Leptin. Methods： The 400 samples were collected from January to July 2007 in the affiliated Chinese medicine hospital, divided them into two groups： hyperuvicemia group （190 cases）, control group （210 cases）, measured the indexes including height, body weight, BMI, blood pressure and analyze the SUA, TG, TC, HDL-C, LDL-C, VLDL-C, use ELISA to detect the serum Leptin. Results： The indexes of SUA, TG, body weight and BMI increased and HDL-C had decreasing trend between hyperuricemia and control group. There are correlation between Leptin and SBP, DBP and BMI. Conclusions： Leptin participate in metabolic disorder and correlated with some indexes of metabolism syndrome. Leptin may be a part in the cause of hyperuricemia, obesity and metabolic disorder.