不同浓度七氟醚在择期手术病人全麻诱导时效果分析

Effect of general anesthesia induction with different concentration of sevoflurane

目的:评估两种不同浓度七氟醚对全麻诱导的影响。方法:60例ASAⅠ～Ⅱ级择期行胸腹颈部手术的病人随机分为两组:5%七氟醚+维库溴胺组及8%七氟醚+维库溴胺组,每组的病人给予相应的七氟醚浓度和5L/min的氧流量,插管前由面罩实施诱导,患者清醒后对七氟醚诱导的感受进行评价。结果:两组意识消失的时间间隔和睫毛反射消失的时间间隔有统计学差异(P<0.05),每组心率在诱导前和插管后有上升。每组诱导前和插管前收缩压和舒张压均有统计学意义(P<0.05),插管后与诱导前和插管前相比,收缩压、舒张压和心率均有统计学差异,两组同一时段相比收缩压,舒张压及心率无统计学差异(P>0.05)。不良反应发生率相似,对七氟醚诱导满意率也无差别(P>0.05)。结论:8%的七氟醚麻醉诱导对于成年人有更多的优势。

Objective： To assess the effect of rapid general anesthesia induction with different concentration of sevoflurane. Methods： Sixty ASA class Ⅰ～Ⅱ patients undergoing elective thorax, abdomen,neck sur gery were randomly devided into two groups. 30 cases for each group： Ⅰ ： 5% sevfiuraneq-vecuronium, group Ⅱ ： 8% sevflurane＋vecuronium, all patients took the two different concentration sevoflurane with 5 L/min O2 by a facemask induction before tracheal intubation. After operation, all patients were asked to describe the impression about sevflurane. Results： The time span at the vanished conscionsness and eyelashes refelect both have significant difference in these two groups （P〈0.05）. HR has significantly varied at the time point of pre-induction, pose-tracheal intubation in both group （P〈0.05）. SBP, DBP have the same change and significant variety at the time points of pre-induction, pre-tracheal, pose-tracheal intubation in group Ⅰ,Ⅱ respectively, but the data of SBP, DBP, HR has no difference at the same time point between group Ⅰ and Ⅱ （P 〈0.05）. The patients showed satisfaction about the effect of sevoflurane and no significant difference in tussis, throat hyperkinesia, increasing secretion and agitation of induction between group Ⅰ and Ⅱ （P 〉0.05）. Conclusion： To the rapid adult induction of general anesthesia, 8% sevoflurane show to more advantage of 5% sevoflurane.