祛瘀宁心丸治疗不稳定型心绞痛的疗效及其血清C-反应蛋白的影响

Effects of Quyuningxin pill to unstable angina pectoris efficacy and serum C-reactive protein

目的:观察祛瘀宁心丸对冠心病不稳定型心绞痛(UA)患者的临床疗效及其血清C-反应蛋白(CRP)浓度的影响,探讨其治疗不稳定型心绞痛的作用机制。方法:将符合入选标准的60例UA患者随机分为西药常规治疗加祛瘀宁心丸组(治疗组,30例)和西药常规治疗组(对照组,30例),疗程均为4周,观察患者心绞痛、临床证候及心电图改变情况。并分别于治疗前后检测患者血清CRP浓度。结果:治疗组心绞痛缓解率、临床证候及心电图总有效率分别高于对照组(89.29%、89.29%、75.0%vs66.67%、66.67%、55.56%,P<0.05);治疗组治疗后CRP浓度低于对照组(3.8±0.9vs5.8±1.8,P<0.05)。结论:祛瘀宁心丸能够显著改善不稳定型心绞痛(浊瘀互结证)患者的心肌缺血、缺氧,缓解心绞痛及心电图表现。

AIM： To observe the clinical effect of Quyuningxin pill on the serum concentration of C-reactive protein （CRP） from coronary heart disease （CHD） patients with unstable angina pectoris, and explore the related mechanisms. METHODS： Sixty patients of CHD with unstable angina pectoris were divided randomly into treatment group （30 cases ） and control group （30 cases）. The treatment group was given conventional western medical combined with Quyuningxin pill. The control group was given conventional western medical only. The course of treatment lasted for four weeks. The serum CRP concentration was measured before and after treatment. The changes of angina pectoris and other clinical syndrome as well as electrocardiogram were also observed. RESULTS： The serum concentration of CRP of Quyuningxin pill treated group was decreased markedly comparing with that of control group （3.8±0.9 vs 5.8 ＋ 1.8, P 〈0.05）. After the treatment, the total effective rate of angina pectoris remission, clinical syndrome, electrocardiogram in treatment group were significantly higher than those in the control group （89.29%, 89.29%, 75.0% vs 66.67%, 66.67%, 55.56% P 〈 0.05）. CONCLUSION： Quyuningxin pill can significantly improve myocardial ischemia related symptoms together with the serum CRP concentration in the patients with unstable angina pectoris.