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己酮可可碱和2-脱氧腺苷提高冷冻复温后精液质量的研究 被引量：1

Study on improving the quality of frozen-thawed sperm with pentoxifylline and 2-deoxyadenosine in vitro
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摘要 在光学显微镜下观察和测定了己酮可可碱（PF）和2－脱氧腺苷（2－DA）在体外对冷冻复温后精液精子的活率、活力及其毛细管穿透值的影响。结果显示PF和2－DA均能提高冷冻复温后精子的活率、活力及其毛细管穿透值，其最适浓度分别为4．0mmol／L和2．0mmol／L，与对照组比较均有显著性差异（P＜0．01）。两级间比较，2－DA优于PF（P＜0．01）。提示PF与2－DA合用不具有协同作用，反而有相互抑制作用，认为单独使用2－DA比合用PF效果更好。 The effects of pentoxifylline (PF) and 2-deoxyadenosine (2-DA) on the sperm riability and motility were evaluated and sperm glass capillary penetration was assayed under light hacroscope after the frozen-thawed sperm was incubated with PF or 2-DA in vitro. Results:Both PF and 2-DA could improve the sperm viablity, motility and sperm glass capillary penetration.Their optimal concentration were 4.0 mmol/L and 2.0 mmol/L respectively (compared with contrd, P<0.01). The effects of 2-DA were better than that of PF (compared between two drug groups, P<0.01).
作者 刘忠国 李冰清 申东亮 王沛涛 崔向东 刘金刚
机构地区 青岛医学院附属医院泌尿外科 青岛医学院附属医院低温医学科
出处 《临床泌尿外科杂志》 1998年第7期319-323,共5页 Journal of Clinical Urology
关键词 己酮可可碱 2-脱氧腺苷 冷冻复温 男性 不育症 Pentoxifylline 2-Deoxyadenosine Freezing-thawing Spermatozoa
分类号 R698.2 [医药卫生—泌尿科学]
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参考文献8

  • 1Woolley DM, Richardson DN. Ultrastructural injury to human spermatozoa after freezing and thawing. J Reprod Fertil, 1978,53:389.
  • 2Hoskius, Casillas. Function of cyclic nucleotides in mammalian spermatozoa. In:Greep RO,Astwood EB (eds). Handbook of physiology. Vol V: Am Physiol Soc Wanshington DC, 1975. 453-454.
  • 3Rees JM, Ford WCL, Hull MGR. Effect of caffeine and of pentoxifylline on the motility and metabolism of human spermatozoa, J Reprod Fertil, 1990,90:147.
  • 4邓嘉泰.人精子对地鼠卵穿透试验的最新进展[J].国外医学：计划生育分册,1989,8(4):198-198.
  • 5Aparicio. Therapeutical use of pentoxifylline indisturbed male fertility. Singapore Med J, 1979,20 (Suppl 1):43.
  • 6Paul M,Moohan JM, Lindsay KS. Individual dose responses to pentoxifylline human sperm assessed by CASA. J Reprod Fertil,1992,10:92.
  • 7Wang R,Bell M,Hellstrom WJG,et al, Post-thaw sperm motility, cAMP concentration and membrane lipid peroxidation after stimulation with pentoxifylline and platelet activating factor,International Journal of Andrology, 1994,17:169.
  • 8Aitken RJ, Mattei A, Irvines. Paradoxical stimulation of human sperm motility by 2deoxyadenosine. J Reprod Fertil, 1986,78-515.

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同被引文献12

  • 1刘华屏,李保芬,邓艳萍,楼雅卿.中国健康志愿者口服多剂量己酮可可碱普通肠溶片的稳态浓度[J].中国临床药理学杂志,1995,11(3):152-155. 被引量：5
  • 2Adam P,Richter E,Adam O,et al. The effect of physical activity on absorption and metabolism of an orally applied drug(pentoxifylline).Eur J Med Res,1999,4(12):525
  • 3McCarty MF. The reported clinical utility of taurine in ischemic disorders may reflect a down-regulation of neutrophil activation and adhesion. Med Hypothesis,1999,53(4):290
  • 4Angelides NS,Minas C. Can aortocoronary and peripheral venous bypass graft patency be improved by administration of pentoxifylline on a long term basis?Cardiologia, 1999,44(12): 1059
  • 5Sheridan BC,Mclntyre RC, Meldrum DR, Fullerton DA. Pentoxifylline treatment attenuates pulmonary vasomotor dysfunction in acute lung injury. J Surg Res, 1997,71:150
  • 6Periaslov AA,Chuklin SM,Detsyk IaB. The use of anti-cytokines in the treatment of acute pancreatitis. Klin Khir,1999,11:6
  • 7Eun BL, Liu XH, Barks JD. Pentoxifylline attenuates hypoxic - ischemic brain injury in immature rats. Pediatr Res,2000,47(1):73
  • 8Balog DL, Epstein ME, Amodio GM. HIV wasting syndrome :treatment update. Ann Pharmacother,1998,32(4):446
  • 9Garcia CF,Orts AM,Morant VA,et al. Recurrent aphthous stomatitis and clinical response to pentoxifylline. Acta Otorrinolaringol Esp,1999,50(8) :671
  • 10Clark SC,Sudarshan C,Roughan J,Flecknell PA,Dark JH. Modulation of reperfusion injury after single lung transplantation by pentoxifylline,inositol polyanions,and sin-1. J Thorac Cardiovasc Surg,1999,117:556

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临床泌尿外科杂志
1998年 第7期

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