单纯疱疹病毒Ⅱ型和人乳头瘤病毒的感染与人工流产术后不孕症的关系

The relationship between herpes simplex virus Ⅱ,human papillomavirus infection and infertility after artificial abortion

目的探讨性传播病毒和不孕症的关系。方法应用聚合酶链反应（ＰＣＲ）对６０例人工流产术后不孕症妇女和３９例正常妇女进行了生殖道单纯疱疹病毒Ｉ型（ＨＳＶ２）和人乳头瘤病毒（ＨＰＶ）的检测。结果不孕组和对照组ＨＳＶ２的阳性检出率分别是８０．０％和２５．５％，两组间有极显著性差异（Ｐ＜００１）；ＨＰＶ的阳性率分别是５３３％和３３３％，两组间无显著性差异（Ｐ＜０．０５）；ＨＳＶ和ＨＰＶ在两组中的混合感染的阳性率分别是４３．３％（２６／６０）和２３．１％（９／３９），两者有显著性差异（Ｐ＜０．０５）。表明ＨＳＶ２或ＨＳＶ２和ＨＰＶ的混合感染与人工流产术后不孕症有显著的相关性，很可能是不孕的原因之一。两组９９份标志中，ＨＳＶ２和ＨＰＶ混合感染的阳性率为３５．３５％，统计学分析表明，ＨＳＶ２和ＨＰＶ感染与不孕有极显著的相关性χ＝１２．５，Ｐ＜０．０１。

In order to study the relationship between infection of sexually transmitted virus Herpes simplex virus II (HSV2),Human papillomavirus (HPV)and female infertility after artificial abortion,we collected 60 genital samples from infertile women who had accepted artificial abortions and 39 genital samples from normal women.Polymerase chain reaction(PCR) was used to detect HSV2 and HPV.The results were compared by x2.The positive rate of HSV2 in infertile and normal women were 80.0% and 25.6% respectively, there was a significant difference (P<0.01);but that of HPV were 53.5% and 33.3%,which slowed no significant difference (P>0.05).Mixed infection rates of HSV2 and HPV were 43.3% and 23.1% in infertile and normal women,a significant difference(P<0.05) was statistically calculated.The results showed that there was a relationship between infertility after artificial abortion and genital infection of HSV2 and HPV or mited infection of HSV2 and HPV. Taking total 99 genilal samples into calculation,the mired infection rate of HSV2 was35.35%,a significant relatedness of HSV2 and HPV infection to infertility was proved by χ2,χ2=12.5,P<0.01.