尼莫地平对妊高征患者视网膜中央动脉血流的影响

The Effect of Nimodipine on Retinal Blood Flow in Pregnancy Induced Hypertension

目的观察尼莫地平对妊高征患者视网膜中央动脉血流的影响。方法应用彩色多普勒超声，检测１４例妊高征患者口服尼莫地平前后视网膜中央动脉血流变化，计算搏动指数（ＰＩ），并与同期１４例静脉滴注硫酸镁治疗者进行比较。结果口服尼莫地平后视网膜中央动脉ＰＩ显著降低，由０９２±０１４降低至０７５±０２２。同时收缩压由２０７±２５ｋＰａ（１ｋＰａ＝７．５ｍｍＨｇ）降低至１９８±１５ｋＰａ，舒张压由１４４±２３ｋＰａ降低至１３６±１９ｋＰａ。结论尼莫地平可扩张视网膜中央动脉，对脑部其它小动脉可能也有相似作用。

Objective To assess the effects of nimodipine on retinal blood flow in patients with pregnancy induced hypertension (PIH).Methods Fourteen patients were studied with color flow Doppler before and after 30 mg nimodipine administered orally, while other fourteen patients received intravenous magnesium sulfate as control group. Central retinal artery flow velocity waveforms were measured and pulse index (PI) were calculated.Results Nimodipine reduced the central retinal artery PI significantly from 0.92±0.14 to 0.75±0.22. It also reduced systolic blood pressure from 20.7±2.5 kPa to 19.8±1.5 kPa and diastolic blood pressure from 14.4±2.3 kPa to 13.6±1.9 kPa.Conclusions Nimodipine may dilate central retinal arteries. Changes in pulsatility index in retinal arteries maybe indicative of similar changes in other cerebral vessels. Nimodipine may be another choice of PIH therapy.