长效托宁救治有机磷农药中毒临床分析

Clinical Anglysis of Effects of Penehyclidine Hydrochloride Injection on Cases of Organophosphorus Poisoning

目的:通过临床对照了解长效托宁救治有机磷农药中毒的作用和优缺点。方法:随机将口服有机磷农药中毒患者分为对照组和试验Ⅰ组,经其它途径中毒的定为试验Ⅱ组。对照组应用氯磷定和阿托品常规治疗,试验Ⅰ组和试验Ⅱ组用氯磷定和长效托宁救治。结果:对照住16例,死亡1例,试验Ⅰ组35例,死亡1例,死亡原因与长效托宁无明显关系;试验Ⅱ组17例,无死亡。在同等情况下长效托宁用药次数,用药总量均明显小于阿托品(P<0.05),副作用小。结论:长效托宁救治有机磷农药中毒优于阿托品。

Objective To evaluate the advantage and the effects of Penehyclidine Hydrochloride Injection on cases of organophosphorus poisoning. Methods 51 cases of organophosphorus poisoning（opp）by digestive tract way were randomly divided into therapy group I （n=35） and control group（n=16）, 17cases of organophosphorus poisoning by other ways into group II. The control group were treated by pyraloximi Methochloridum and atropine, and the therapy group I, II by pyraloximi Methochloridum and Penehyclidine Hydrochloride Injection. Results There was one case died in the control group. No case died in the therapy group II, one case died in the thempy group I, the cause of whose death was not with relation to Penehyclidine Hydrochloride Injection. In the same condition, Penehyclidine Hydrochloride Injection had slighter side effect, less times of treatment and less total dose. Conclusion Penehyclidine Hydrochloride Injection has an advantage over atropine in treatment of organophosphoms poisoning.