重组白细胞介素-2腔内灌注并化疗治疗癌性胸水临床观察

A clinical observation fo interlukin Ⅱ inter-pleural injection combining with chemotherapy for malignant pleural effusion

目的：考察及确认重组白细胞介素-2（IL-2）腔内灌注并全身化疗对癌性胸腔积液的疗效及IL－2介入治疗的毒副作用。方法：观察48例经病理确诊的癌性胸水患者，随机分为治疗组与对照组各24例，治疗组在尽量抽去胸水后胸腔内灌注IL－240－60万u／m2体表面积，每周1－2次，连续4周，同时进行全身化疗，对照组仅给单纯化疗，两组给予同一化疗方案。结果：按WHO规定的癌性渗液评定标准进行疗效评定，治疗组完全缓解（CR）13例，部分缓解（PR）8例，总缓解率（CR）＋（PR）87．5％（21／24），显著高于对照组58．33％（14／24，P＜0．01），毒副反应主要表现为发热、畏寒。结论：IL－2治疗癌性胸水疗效肯定，合并化疗效果更佳，值得推广。

Objective: In order to avalue the efficency of IL - 2 inter - Pleural injectedly combining with all body chemotherapy and their side effects. Methods: We studied 48 cases with malpnact evidence, which were divided into two groups randomly. The observed group were given IL - 2 after the malignant pleual effusion was drown out as much as possible, the injecting was 400 thousand unit to 600 thousand unit/m2 each time and was given one to two time each week.Theperiod of treatrent was four meeks. At same bine, all body chemotheropy was given. The control group were given only usingsimply chemotherapy. Results:Show that overall effective rate was 87. 5%. However the control group was 58. 33%. Themain side effect was fever and vigat. Conclusions: Treatment of IL - 2 for malignant pleural is poSitive, and combiningchemotherapy is more better than that.