放射诱导肿瘤血管生成及其机制研究进展
摘要
随着放疗新技术的出现及放射生物学观念的更新，放疗在肿瘤治疗中的地位越来越重要。一系列研究证实放射线可激活细胞内多种信号转导通路，这些通路的激活可促进肿瘤血管生成，进而促进肿瘤复发转移。关于放射与肿瘤血管生成之问关系的研究较少，以下就这方面的研究进展加以综述。
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2009年第4期337-340,共4页
Chinese Journal of Radiation Oncology
基金
第44批博士后科学基金资助项目（20080440077）
参考文献51
-
1Andarawewa KL, Erickson AC, Barcellos-Hoff MH, et al. Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res,2007 ,67 :8662-8670.
-
2Choi SY, Kim MJ, Kang CM, et al. Activation of Bak and Bax through c-abl-protein kinase Cdeha-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells. J Biol Chem,2006,281 : 7049-7059.
-
3Zhao W,Goswami PC,Robbins ME. Radiation-induced up-regulation of MMP2 involves increased mRNA stability, redox modulation, and MAPK activation. Radiat Res,2004 ,161:418-429.
-
4Mao XW. A quantitative study of the effects of ionizing radiation on endothelial cells and capillary-like network formation. Technol Cancer Res Treat,2006,5 : 127-134.
-
5Ahmad M, Khurana NR, Jaberi JE. Ionizing radiation decreases capillary-like structure formation by endothelial cells in vitro. Microvasc Res ,2007,73 : 14-19.
-
6Abdollahi A, Griggs DW, Huber PE, et al. Inhibition of alpha( v ) beta 3 integrin survival signaling enhances antiangiogenic and anti- tumor effects of radiotherapy. Clin Cancer Res, 2005,11 : 6270- 6279.
-
7Albert JM,Cao C, Lu B,et al. Integrin alpha v beta 3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer models. Int J Radiat Oncol Biol Phys, 2006,65 : 1536-1543.
-
8Monferran S, Skuli N, Toulas C, et al. Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionizing radiation through ILK and RhoB. Int J Cancer,2008,123:357-364.
-
9Song CW, Levitt SH. Effect of x irradiation on vascularity of normal tissues and experimental tumor. Radiology, 1970,94 : 445-447.
-
10Sonveaux P, Brouet A, Feron O, et al. Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy. Cancer Res, 2003,63: 1012- 1019.
-
1武霞,刘学键,蒋丽华,盖龙娴,汪延明.保乳术后放疗新技术的应用研究[J].中华临床医师杂志（电子版）,2013,7(23):297-298.
-
2龚伟,廖洪,庞晓琳,刘丽华.调强适形放疗联合化疗治疗直肠癌术后复发的疗效观察[J].浙江临床医学,2014,16(8):1252-1254. 被引量：6
-
3王璐璐,孔为民.放疗在宫颈癌治疗中的应用[J].医学综述,2015,21(4):627-629. 被引量：10
-
4王伟平,胡克,张福泉.放疗新技术在胰腺癌治疗中的应用[J].协和医学杂志,2015,6(4):300-304. 被引量：4
-
5姚丽红,王俊杰.立体定向放疗及放射性粒子植入治疗脊柱转移瘤的研究进展[J].癌症进展,2014,12(6):537-540. 被引量：2
-
6丘全胜.三维适形放疗同期化疗治疗局部晚期鼻咽癌的近期疗效观察[J].中国医药指南,2013,11(21):191-192. 被引量：1
-
7韩俊庆,李冠贞.局部晚期非小细胞肺癌治疗进展 放射治疗[J].山东医药,2003,43(33):55-56. 被引量：1
-
8孔为民,吴令英.关注放疗新技术及其在妇科恶性肿瘤领域的应用[J].中华妇产科杂志,2013,48(9):641-643. 被引量：5
-
9袁选举,王贤和,陈萍,李林均,李芳,蔡晓军.调强放疗配合腔内后装治疗中晚期宫颈癌的临床观察[J].山西医药杂志（下半月）,2013,42(1):84-86. 被引量：8
-
10朱小东.鼻咽癌放射治疗的研究进展[J].临床肿瘤学杂志,2003,8(2):156-158. 被引量：1
