表达MHCⅡ类分子的转基因鼠甲状腺细胞对自身T细胞的影响

Effect of thyrocytes from transgenic mice expressing thyroid specific MHC class Ⅱ on autologous T lymphocyte in vitro

从转基因小鼠分离表达主要组织相容性复合体（MHC）Ⅱ类分子的甲状腺细胞与小鼠自身T细胞共同培养，结果甲状腺细胞未能刺激T细胞的增殖和活化，相反，促进了自身CD4^＋T细胞凋亡。

Thyrocytes expressing MHC class Ⅱ molecules were separated from transgenic mice and were co-cultured with autologous spleen T lymphocytes. T cells did not proliferate and were not activated, but CD4^ ＋ T cells were promoted into apoptosis.