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球型脂联素对高糖环境NIT-1胰岛β细胞功能的影响

Effect of globular adiponectin on the function of NIT-1 cells under high glucose medium
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摘要 用β细胞株NIT—1来研究球型脂联素对高糖损伤β细胞分泌功能及相关基因表达的影响。结果显示球型脂联素可恢复部分β细胞功能相关基因的表达，抑制高糖诱导NAD（P）H氧化酶组分p47phox表达增加，但未能改善高糖诱导的胰岛素mRNA水平下降及胰岛素分泌缺陷。 The effect of globular adiponectiin（gAd）on the function of NIT-1 cells under high glucose medium was investigated. The results showed that gad could eompletely block the increase of NADPH oxidase components p47phox expression and recover mRNA expression of pancreatic duodenal homeobox-1 ,paired box gene 6 ,glucose transpoter 2,and glueokinase except neurogenic differentiation factor 1 （P〈0. 05 or P〈0. 01 ）. Whereas, impaired insulin secretion and mRNA expression at high glucose concentration were not significantly improved by gAd.
作者 周嘉 李焱 杨川 徐明彤 李芳萍 严励 程桦 傅祖植
机构地区 中山大学附属第二医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2009年第3期316-317,共2页 Chinese Journal of Endocrinology and Metabolism
基金 基金项目：广东省自然科学基金项目（04300232）
关键词 NIT-1 β细胞株 球型脂联素 NAD(P)H氧化酶 NIT-1 cell lines Global adiponectin NAD（P） H oxidase
分类号 R587.1 [医药卫生—内分泌] R587.2 [医药卫生—内分泌]
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参考文献9

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二级参考文献10

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中华内分泌代谢杂志
2009年 第3期

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