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糖尿病大鼠胰岛β细胞FoxO1表达对细胞凋亡的影响 被引量：2

Effect of FoxO1 expression on islet β-cells apoptosis in diabetic rat
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摘要 以高糖高脂饲料及链脲佐菌素诱导SD大鼠建立2型糖尿病模型，结果发现叉头转录因子（FoxO1）[细胞核内（15．00±1．15vs6．45±0．62）％，P〈0．05]、半胱天冬蛋白酶3（caspase-3）[（23．73±1．48vs6．30±2．20）％，P〈0．01]在糖尿病大鼠胰岛β细胞的表达和β细胞凋亡率[（22．29±1．84vs6．25±2．42）％，P〈0．01]均高于正常大鼠；并且FoxO1（核内）与caspase-3高表达的胰岛细胞正是发生凋亡的胰岛细胞。因此，FoxO1可能参与2型糖尿病胰岛β细胞凋亡的调控。 SD rats were injected with streptozotocin and fed with high fat diet,used as type 2 diabetic model. Transcription factor FoxO1 [ in nucleus （ 15. 00 ± 1.15 vs 6.45 ±0. 62 ） %, P〈0.05 ], Caspase-3 [ （ 23.73 ± 1.48 vs 6.30±2.20）% ,P〈0.01 ] expressions in pancreatic istet β cells and the positive rate of islet β cells apoptosis[ （22.29±1.84 vs 6.25±2.42）% ,P〈0. 01 ] in diabetic rats were higher than those of control rats. The islet cells which highly expressed FoxOl （in nucleus）and caspase-3 were just the apoptotic islet cells. Therefore, FoxO1 may be involved in regulating apoptosis of islet β cells in type 2 diabetes.
作者 陈丹燕 邓华聪 南静 冯正平 刘强 秦登优 周恒宇
机构地区 重庆医科大学附属第一医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2009年第3期320-323,共4页 Chinese Journal of Endocrinology and Metabolism
基金 基金项目：国家自然科学基金资助项目（30771038,30570744,30370670） 教育部博士生基金（20050631009） 教育部重点项目KJ050314 教育部第二批“春晖计划” 重庆市教委基金渝教科[2003]7号文
关键词 FOXO1 胰岛Β细胞 半胱天冬蛋白酶3 细胞凋亡 糖尿病 实验性 FoxO1 Pancreatic islet β-cell Caspase-3 Apoptosis Diabetes mellitus,experimental
分类号 R587.1 [医药卫生—内分泌] R733.71 [医药卫生—肿瘤]
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参考文献12

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同被引文献18

  • 1赵文惠,萧建中,杨文英,王娜,王昕,陈晓平,卜石.肝脏胰岛素抵抗与肝糖输出调控基因表达的关系[J].中华肝脏病杂志,2006,14(1):45-48. 被引量：27
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中华内分泌代谢杂志
2009年 第3期

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