摘要
目的:探讨PET/CT在监测卵巢癌术后复发、转移中的应用价值。方法:回顾性分析20例卵巢癌术后患者全身18F-FDGPET/CT显像结果,临床随访时间6~18个月。确诊依据为手术病理检查、穿刺活检、多种影像学检查和临床随诊。结果:20例患者中,13例(65%)患者最终确定有复发或转移,PET/CT诊断复发转移病例的灵敏度为100.0%,特异性为85.7%、准确性为95.0%。13例患者病理或随访确诊32处病灶,PET/CT共发现29处阳性病灶。PET/CT诊断复发或转移灶的灵敏度、特异性、准确率、阳性预测值及阴性预测值分别为84.3%(27/32)、81.8%(9/11)、83.7%(36/43)、93.1%(27/29)和64.2%(9/14)。20例患者中,11例肿瘤标志CA125升高,10例PET/CT检查显示复发或转移病灶,并经最终结果证实,1例血清CA125水平升高但PET/CT未检出转移灶,至随访结束未发现复发或转移。另有3例血清CA125水平正常,但PET/CT检查发现转移灶。结论:18F-FDG PET/CT检查诊断卵巢癌术后复发转移灵敏度、特异性和准确率较高,在卵巢癌术后监测中有重要作用。
OBJECTIVE： To evaluate the clinical value of PET/CT in detecting and diagnosing the recurrence and metastasis of ovarian carcinoma. METHODS： A retrospective study was done on 20 patients with ovarian cancer. The duration of followup was 6--18 months. The diagnosis of recurrence and metastasis was based on pathologic examination, multi modality imaging and clinical follow-up. RESULTS= Thirteen （65 %） of 20 patients had recurrence and metastasis. The sensitivity, specificity and accura- cy of PET/CT in detecting recurrence and metastasis were 100.0%, 85.7% and 95.0%, respectively. Thirty-two lesions were confirmed in 13 patients, and PET/CT imaging found 29 positive lesions. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of PET/CT in detec- ting recurrence and metastasis of all lesions were 84.3% （27/32）, 81.8%（9/11）, 83. 7% （36/43）, 93. 1%%（27/29） and 64. 2%/00 （9/14）respectively. The serum carbohydrate antigen（CA）125 was increased in 11 patients, 10 were confirmed recurrence of metasta- sis, the other 1 was closely follow up, but no sign of recurrence or metastasis was found. PET/CT detected recurrence and metastasis in 3 patients whose serum CA125 was normal. CONCLUSION： 18 FFDG PET/CT can detect the recurrence and metastasis of ovarian cancer with high sensitivity, specificity and accuracy and it has high value in monitoring and locating the recurrence of metastasis.
出处
《中华肿瘤防治杂志》
CAS
2009年第11期867-869,共3页
Chinese Journal of Cancer Prevention and Treatment
