摘要
目的观察胃癌组织中生长抑素(SS)表达与表皮生长因子受体(EGFR)表达的相互关系,探讨其抑癌的可能机制.方法应用免疫组化LSAB法及即用型SP法,对147例各种组织学类型胃癌中SS及EGFR的表达进行观察比较,并对其中127例患者进行预后随访.结果胃癌中SS阳性表达率为257%.EGFR阳性表达率543%.SS阳性及SS阴性两组胃癌EGFR的表达有明显差异(P<001).SS阳性胃癌组EGFR的表达明显减少;SS阴性胃癌组EGFR的表达增多.SS阳性胃癌较SS阴性胃癌生存期长,预后好(P<001).相反,EGFR阳性胃癌较EGFR阴性胃癌生存期短,预后差(P<001).尤其是伴有SS阴性表达的EGFR阳性胃癌预后更差.结论SS及EGFR在人体胃癌组织中的表达有一定拮抗性.SS阴性的EGFR阳性胃癌预后更差.SS的抑癌机制之一可能是干扰了生长因子的合成,影响了细胞内调节细胞生长信号的传递。
AIM To study the relationship between the expressions of SS and epidermal growth factor receptor (EGFR) in GC and the possible mechanism of inhibitory effect of SS on tumor growth. METHODS Expressions of SS and EGFR in 147 patients with GC were observed by immunohistochemistry. Among them, 127 patients were followed up. RESULTS There was a difference in EGFR expression between SS positive and SS negative GC groups ( P <0 01). EGFR expression in SS positive GC group was decreased and increased in SS negative group. EGFR positive GC patients had shorter survival period than EGFR negative GC ( P <0 01). EGFR positive GC with negative SS had the shortest survival period. CONCLUSION There is certain antagonist between the expression of SS and EGFR in human GC. One of the mechanisms of tumor inhibition by SS could be the interference with the synthesis of autocrine growth factors by tumor cells and with transmission of intracellular signals that regulate cell growth.
关键词
胃肿瘤
病理
淋巴转移
生长抑素
受体
stomach neoplasms/pathology
adenocarcinoma/pathology
lymphatic metastasis
somatostatin/analysis
receptors, epidermal growth factor urogastrone