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性激素与原发性肝癌 被引量:1

SEX HORMONE AND PRIMARY LIVER CANCER
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摘要 运用RIA法对76例男性肝癌及10例女性肝癌患者血清睾丸酮(T)、雌二醇(E2)及孕酮(P)水平进行测定。结果:男性肝癌手术组及非手术组血清T水平显著高于肝良性病变组及正常对照组,E2水平则显著低于后两组;雄/雌激素比例(T/E2)显著高于后两组;肝癌切除后T水平下降,E2水平升高,T/E2比值下降,与肝良性病变组及正常对照组比较无显著差异。女性肝癌组T、E2水平与肝良性病变组及正常对照组比较无显著差异,但T/E2比例明显高于正常对照组。男、女肝癌组的P水平均未见明显改变。本组资料结果提示:高T水平及低E2水平与肝癌有关。 The serum level of testosterone (T), estradiol (E 2) and progesterone (P) in 86 cases with primary liver cancer (PLC) (male:76 cases; female:10 cases) was determined by RIA method. The result showed that for male cases, serum level of T and ratio of T/E 2 in operation group and nonoperation group was significantly higher than that in benign hepatic diseases group (BHD group) and normal control group (NC group), but the value of E 2 obviously lower than the later two groups. After tumor resection, the level of E 2 increased, while serum level of T and value of T/E 2 decreased, which had no significant difference as contrasted with BHD group and NC group. The serum level of T,E 2 in female PLC group made no difference to BHD group and NC group, but the value of T/E 2 much higher than NC group. No obvious changes of the serum level of progesterone can be observed in both male and female cases. Our research showed that high serum testosterone level and low estradiol level may be concerned with PLC. The possibility and importance of sex hormone imbalance on initializing and developing of PLC is suggested.
出处 《中国普外基础与临床杂志》 CAS 1998年第4期214-216,共3页 Chinese Journal of Bases and Clinics In General Surgery
关键词 肝癌 性激素 肿瘤发生 Primary liver cancer Sex hormone
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  • 1Baum IK, Bookstein JJ, Holtz F, et al. Possible association between benigm hepatomas and oral ocntraceptives. Lancet, 1973: ii(7835 ):926.
  • 2蒋国祯,徐冠南,李先兴.影响女性肝细胞癌预后因素初步探讨[J].中国微创外科杂志,1997(4):6-8. 被引量:1
  • 3Yu MW, Cheng CJ. Elevated serm testosterone levels and risk of hepatocellular carcinoma. Cancer Res ,1993;53(4):790.
  • 4Farinati F, Demaria N, Chiarmonte M. et al.Hormone treatment of hepatocellular carcinoma. J Hepato,1991:12(3):402.

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