观察洛伐他汀对老年单纯收缩期高血压患者脉压及动脉弹性的影响

To observe the effects of lovastatin on pulse pressure and arterial flexibility in elderly isolated systolic hypertension patients

目的观察他汀类药物对血脂正常的老年单纯收缩期高血压（ISH）患者脉压及动脉弹性的影响。方法随机将68例ISH患者分成治疗组及对照组，对照组给予贝那普利口服，每次10mg，1次／d；治疗组在对照组治疗基础上加用洛伐他汀，20mg／次，每晚1次，观察两组患者治疗前后收缩压（SBP）、舒张压（DBP）、脉压（PP）、颈动脉一挠动脉脉博波速度（C-RPWV）及颈动脉．股动脉脉搏波速度（C-FPWV）的变化。结果治疗后两组SBP、PP、C—RPW及CFPWV均有所下降，随着治疗时间的延长，治疗组较对照组PP、C-RPWV及c-FPWV显著降低（P〈0．01）。结论他汀类与血管紧张素转换酶抑制剂合用，有益于控制患者的脉压及脉搏波速度，改善动脉弹性。

Objective To observe the effects of the statin drugs on pulse pressure and arterial flexibility in elderly isolated systolic hypertension （ISH）patients with normal blood lipids. Methods 68 ISH patients were randomly divided into treatment group and control group, patients in the control group were given benazepril 10 mg/d,once,while the ones in the treatment group, based on the control group＇s therapy, were additionally used lovastatin,20 mg in every evening. Observe the chang of their, systolic blood pressure （SBP）, diastolic blood pressure（DBP）, pulse pressure （PP）, carotid-radial pulse wave velocity （C-RPWV）and carotid-femoral pulse wave velocity（C-FPWV） from the twe groups before and after treatment. Results After treatment,in both groups, SBP, PP, C-RPW and C-FPWV has all declined, with the treatment time going, a significantly decline in patients＇ PP, C-RPWV and C-FPWV can be easily obtained, when compared with the control （P 〈 0. 01 ）. Con- clusion The combination of statins and angiotensin-converting enzyme inhibitor is beneficial control patients＇ pulse pressure and pulse wave velocity as well as improve arterial flexibility.