P16 P53 Rb 和 NM23 在子宫内膜间质肉瘤的表达

The Expression of Rb P16 P53 and NM23 inEndometrial Stromal Sarcoma

应用免疫组织化学的方法观察了８例子宫内膜间质肉瘤的Ｐ１６，Ｐ５３，Ｒｂ和ＮＭ２３的表达。结果显示所有８例标本Ｒｂ均表达阳性，而Ｐ１６则表达弱阳性和阴性。８例中有两例表现浸润，破坏最明显，瘤组织穿破子宫，累及周围组织。这两例中，１例ＮＭ２３表达阴性，另１例ＮＭ２３为弱阳性和Ｐ５３弱阳性。８例中Ｐ５３仅此１例阳性。这些结果提示Ｐ１６的表达与Ｒｂ活性负相关。Ｐ５３的表达可能与肿瘤的浸润和进展有关。

To detect the expression of Rb P16 P53 and NM23 in 8 endometrial stromal sarcomas. We examined these proteins by immunohistochemistry methods in 8 primary endimetrial stromal sarcomas. The positive expression of Rb was revealed in all samples,while P16 showed low level or no expression. In two of the eight observed sarcoma remarkably invaded through the break of the uterus and involved the close tissue, one of them was nagative in NM23, the otherd was weak positive in NM23. Only P53 positive expression in 8 samples were observed. The rseult suggested that the expression of P16 and Rb probably is in inverse relationship to endometrial stromal sarcoma.Overexpression of P53 may be correlated with sarcoma invasion and progression, but the expression of NM23 is probably in inverse relationship.