乳腺上皮不典型增生时DNA含量、超微结构及肿瘤相关抗原变化的意义

SIGNIFICANCE OF THE CHANGES OF DNA CONTENT, ULTRASTRUCTURE AND TUMOR RELATED ANTIGNES EXPRESSION IN ATYPICAL HYPERPLASIA OF BREAST

观测正常乳腺、乳腺囊性增生病和乳腺癌细胞核ＤＮＡ含量、细胞超微结构、Ｙ抗原及免疫抑制性酸性蛋白（ＩＡＰ２）表达。结果：上皮增生Ⅰ级细胞与正常乳腺细胞相似；不典型增生细胞ＤＮＡ含量增加，细胞膜和细胞核超微结构出现发育不良及去分化现象，部分不典型增生细胞见异常抗原表达；部分Ⅲ级不典型增生细胞ＤＮＡ含量和超微结构与乳腺癌组织分化Ⅰ级细胞相似。提示在不典型增生阶段，这些细胞的生物学异常和程度与其细胞分化程度。

The DNA content, cellular ultrastructure and the expression of blood group Y antigen and immunosuppressive acidic protein 2(IAP 2) were observed in normal breast, cystic hyperplasia of breast and breast cancer. The results showed: the results observed in the cells of cystic hyperplasia with epithelial proliferation grade Ⅰ were similar to those in normal breast cells. The DNA content increased, the hypoplasia and dedifferentiation features in some structures of cellular membrane and nucleus were observed, and the abnormal antigens expressed in part of the atypical hyperplasic cells. The DNA content and ultrastructure in a part of cells with aypical hyperplasia grade Ⅲ were similar to those in the cells of breast cancer grade Ⅰ. The results indicated that in the couse of atypical hyperplasia, the biological abnormalities and its extent of those cells were closely related to the differentiation extent, the developing tendency and the risk of canceration of the cystic hyperplasia of breast.