p53与p16蛋白在乳腺癌中的表达及其预后意义

p53 and p16 protein expression in breast cancer and its prognostic significance

目的：探讨ｐ５３、ｐ１６两种抑癌基因蛋白表达在乳腺癌预后及转移中的价值。方法：应用免疫组化法对７６例人乳腺癌石蜡包埋组织进行ｐ５３及ｐ１６蛋白表达研究。结果：ｐ５３蛋白表达阳性组肿瘤的组织学分级、腋窝淋巴结转移率高于ｐ５３蛋白表达阴性组，两组相差显著（Ｐ＜０．０５）和非常显著（Ｐ＜０．０１），而ｐ５３蛋白表达阳性组术后生存期则低于阴性组（Ｐ＜０．０１）；ｐ１６蛋白表达阳性组的腋窝淋巴结转移率、术后生存期则均低于阴性组（分别为Ｐ＜０．０１和Ｐ＜０．０５）。

Objective:To evaluate the value of p53 and p16 protein expression in prognosis of breast cancer patients. Methods: p53 and p16 protein expression was examined with immunohistochemical methods in 76 paraffinembeded cases of primary breast cancers. Results: In breast cancer, histologic grade and lymph node metastasis in p53 positive expression group were significantly higher than that in p53 negative expression group (P<0.05, P<0.01) and survival of patients in p53 positive expression group was shorter than that in p53 negative expression group (P<0.01). But survival of patients in p16 positive expression group was lower than that in p16 negative expression group (P<0.05), and lymph node metastasis in p16 positive expression group was lower than that in p16 negative expression group(P<0.01). Conclusion: p53 and p16 protein expression may be an important indicator for judgement of prognosis of breast cancer patients.