表皮生长因子受体在鼻腔鼻窦鳞状细胞癌中的表达

To Study EGFR Expression in Squamous Cell Carcinomas of the Nasal Cavities and Paranasal Sinuses

目的：了解表皮生长因子受体（ＥＧＦＲ）在鼻腔鼻窦鳞癌中的表达情况，并探讨其与鳞癌组织学分级的关系。方法：用免疫组化方法分析４５例鳞癌标本。结果：７７．８％的鳞癌组织中有ＥＧＦＲ表达，ＥＧＦＲ表达有随着鳞癌组织学分级升高而增加的趋势。

Objective:To study the expression of EGFR in squamous cell carcinomas(SCC) of the nasal cavities and paranasal sinuses,and to explore the relationship between its expression and histopathological grade of the SCC.Method:Immunohistochemical analysis was performed on 45 human SCC samples.Result:EGFR expression was detected in 77.8% SCC and there was an increase in the EGFR expression with the increasing grade of malignancy of SCC.Conclusion:The results suggest that an increased reaction of EGFR should appear to be related to histopathological differentiation of SCC.