丙种球蛋白预防肾病综合征患儿上呼吸道感染的临床观察

Clinical study of gammaglobulin on upper respiratory infection prevention in nephrotic syndrome children

目的:观察丙种球蛋白(IVIgG)对肾病综合征(NS)患儿上呼吸道感染的预防效果。方法:40例肾病综合征患儿随机分为对照组与治疗组,每组各20例,两组均采用NS常规治疗,治疗组在此基础上加用IVIgG100～300mg·kg-1.d-1,以5%的葡萄糖溶液使其浓度稀释成3%,静脉滴注,每月1次,连续治疗6个月,记录期间患儿上呼吸道感染情况,检测治疗前、后IgG水平。结果:治疗组上呼吸道感染率(40%,8/20)明显低于对照组(75%,15/20),差异有统计学意义(P<0.05)。治疗组治疗前、后IgG水平分别为(3.52±1.40)、(12.65±1.40)g/L,对照组治疗前、后IgG水平分别为(3.65±1.31)、(8.50±1.52)g/L,治疗组IgG的改善程度明显优于对照组(t=8.981,P<0.01)。结论:IVIgG能明显改善NS患儿的免疫状态,在一定程度上能有效地预防上呼吸道感染。

Objective： To study the preventive effects of gammaglobulin （IVIgG） on upper respiratory infection in nephrotic syndrome （NS） children. Methods： 40 NS children were divided into observing group and control, each group had 20 children, all subjects were treated with conventional therapy. Meanwhile, IVIgG 100 300 mg. KG - 1. d-1 diluted to 3% was injected once/month, continuous for 6 months for observing group. The state of upper respiratory infection and IgG level of pre and post treatment were recorded. Results： Upper respiratory infection rate was significantly lower in observing group（40% ,8/20） than that in control（75%, 15/20）（P 〈 0.05）. The IgG level pre and post treatment were （3.52 ± 1.40） and （ 12.65 ± 1.40） in observing group, but （3.65 ± 1.31 ）and （8.50 ± 1.52）in control. IgG level improved largely in observing group than that in control（ t =8.981 ,P 〈0.01 ）. Conclusions： IVIgG can improve the immune state of NS children, and at certain extent, prevent upper respiratory infection