女性下生殖道中病原微生物的检测分析

Analysis of pathogenic microorganism detected in female lower genital tract

目的:了解女性下生殖道感染患者中淋病双球菌(NG)、解脲支原体(UU)和沙眼衣原件(CT)的感染状况,为临床正确诊断和治疗提供依据。方法:对589例拟诊为生殖道感染的女性患者(病例组)和305例女性正常体检者(对照组)进行阴道分泌物(包括白色念珠菌、滴虫等)常规检查,采用荧光定量PCR法检测NG、UU和CT。结果:病例组UU、CT阳性率(分别为61.8%、23.1%)明显高于对照组(分别为39.5%、5.8%),差异均有统计学意义(P(0.05);病例组UU以单独感染(59.9%)状态为主,而CT和NG以混合感染(69.0%、56.0%)为主,结论:UU、CT可能是女性下生殖道的主要病原微生物,有必要进行常规检查,以便正确指导临床治疗。

Objective： To investigate the infectious state of Micrococcus gonorrhoeae （MG）, ureaplasma urealyticum（UU） and Chlamydiae trachomatis （CT） in female lower genital tract, and to provide diagnostic and therapeutic evidences for clinician. Methods： 589 female patients primarily diagnosed as gential tract infection （ experimental group） and 305 healthy female underwent medical examination（ control group） were given routine vagihal secretions examination（candida albicans, infusorium included ）, fluorescent quantitation PCR were employed to detect MG, UU and CT. Results： The positive rates of UU and CT （61.8% ,23.1% ） were significantly higher in experimental group than that in control（39.5% ,5.8% ）（ P 〈 0.05 ）. UU infection was mainly solo state （59. 9% ）, while CT and MG infection were highly mixed state（69.0% .56.0% ）. Conclusion： UU and CT may be main pathogenic microorganism in female lower genital tract, so it is necessary to take a routine test for female to exclude these infections for the sake of guiding clinical management.