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喉癌的浸润转移与纤维结合蛋白含量表达的相关性研究 被引量:1

Correlation between the infiltration and metastasis and the content and expression of fibronectin in laryngeal cancer
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摘要 目的:探讨喉癌浸润转移与纤维结合蛋白(Fibronectin,FN)的关系。方法:采用琼脂糖单向扩散和免疫酶染色(ABC法)检测喉癌病人血清及喉疾组织中FN的含量及表达。结果:喉疾病人血清中FN含量明显低于对照组,P<0.01,喉癌组织中FN表达于细胞基质中,少部分表达于细胞膜上。结论:喉癌病人血清及组织中FN含量和表达下降与喉癌转移有关。 Objective:To study the correlation between infiltration and metastasis and fibronectin (FN) inlaryngeal cancer. Methods: The content and expression of FN in serum and tumor tissue of laryngeal cancer patients were detected by agrarose simple diffusion and immunohistochemical staining (ABC method). Results:The FN content was significantly lower in patients' serum than that in control group (P<0. 01). In tumor tissue FN mostly distributed in cytoplasm and only a few of it were on the celll membrane. Conclusion:The decrease of FN content and expression in patients' serum and tumor tissue may correlate with the metastasis ofcancer.
出处 《白求恩医科大学学报》 CSCD 1998年第4期368-369,共2页 Journal of Norman Bethune University of Medical Science
关键词 纤维结合蛋白 喉肿瘤 免疫组织化学 laryngeal neoplasms fibronectin immunohistochemistry
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  • 1王瑞年,国外医学消化系疾病分册,1993年,13卷,4期,197页
  • 2Ming S C,Cancer,1977年,39卷,6期,2475页

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