摘要
用免疫组化LSAB法对53例喉鳞状细胞癌(LSCC)癌组织的P53和bc1-2蛋白表达进行了检测。结果表明53例LCSS中25例(47.17%)突变型P53蛋白表达为阳性,同时一些癌旁不典型增生上皮中也有P53表达,说明突变型P53表达可能是LSCC发展的早期事件。此外,在所有检测病例中bc1-2蛋白表达率为69.81%(37/53)。
Expressions of P53 and bcl 2 protein in 53 cases of laryngeal Squamous Cell Carcinoma(LSCC) were determined with immunohistochemical LSAB method.The results showed that in 25 of 53(47 17%) LSCC,the expression of mutant type P53 protein was positive,meanwhile,mutant type P53 protein was also expressed in some dysplastic epitheliums near the cancer tissues.that means the expression of mutant type P53 protein may be the early event in the development of LSCC.The results also indicated the expression rate of bcl 2 protein was 69 81%(37/53) in all LSCC patients.But the correlation between bcl 2 protein expression and P53 protein expression had not been found. \ \
出处
《卫生毒理学杂志》
CAS
CSCD
1998年第2期74-75,共2页
Journal of Health Toxicology