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口腔鳞状细胞癌Rb基因的检测 被引量:1

THE DETECTION OF RB GENE IN ORAL SQUAMOUS CELL CARCINOMA
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摘要 目的研究Rb基因异常与口腔鳞状细胞癌发生及临床病理指标的关系。方法应用地高辛高效引物标记Rb3.6KbDNA探针,结合抗地高辛抗体碱性磷酸酶显色法,对口腔鳞癌病人中Rb基因改变进行了研究。结果在7/28例口腔鳞癌中发现Rb基因结构异常,其中6例出现5.4、4.1及2.3Kb片段缺失,1例出现6.2Kb新片段;Rb缺失与临床病理指标无显著相关性。结论口腔鳞癌中存在Rb基因缺失、重排。 Objective: To study the correlation between abnormality of Rb gene in initiation of oral squamous cell carcinoma (SCC), and to analyze the relationship between deletion of Rb and some clinicopathological parameters.Method: DIGHighPrime Labeled Rb 36Kb DNA probe in combination with antiDIGAP detection system was used in this study.Results: The structural abnormal alterations of Rb gene were found in 7 cases of total samples, in which observed were the deletion of 54, 41 and 23Kb fragment in 6 cases. Rearrangement was detected in one case. Further analyses were carried out to determine whether the deletion of Rb gene correlated with various clinicopathological parameters of the patients. No correlation was found with sex, age, site of primary tumor, level of histopathological differentiation and TNM staging.Conclusion: The abnormalities of Rb gene might be associated with the carcinogenesis of oral SCC.
作者 刘杰 黄洪章
出处 《口腔颌面外科杂志》 CAS 1998年第2期106-108,共3页 Journal of Oral and Maxillofacial Surgery
关键词 RB基因 口腔鳞状细胞癌 基因缺失 基因重排 Rb gene Oral squamous cell carcinoma Gene deletion Gene rearrangement
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