早期颊粘膜鳞癌血管生成的超微结构研究

Ultrastructural studies on angiogenesis of buccal carcinoma in early stage

目的：观察早期颊癌组织内血管生成现象，研究新生血管超微结构特征及其与癌细胞浸润生长的相互关系，探讨肿瘤内血管异常对颊癌局部生物学行为的影响。方法：收集５例早期颊癌手术标本及临床资料，正常人颊部组织作对照，采取组织病理学方法及透射电镜技术进行研究。结果：早期颊癌细胞具有明显的侵袭特征，并诱发新生血管生成；伴随癌细胞的浸润，邻近毛细血管的内皮细胞代谢活跃出现增生表现；新形成的血管结构不完整，癌肿内多处可见结构缺损的毛细血管直接与癌细胞相邻。结论：早期颊癌内结构稳定、结构破坏和新形成血管同时存在，癌细胞局部浸润、漫延与其诱发血管生成相互促进，并表现出侵袭血管的趋势。

bjective: To observe the angiogenesis of buccal carcinoma in early stage and the ultrastructural characters of new vascular and its relationship with carcinoma cell invasion. Methods:Specimens of early buccal carcinoma were collected from 5 patients and examined with histological method and electron microscopic technique, the buccal tissue from health adult was used as the control. Results:Strong invasiveness of the cancer cells in the specimens and active proliferation of the endothelia of capillaries adjacent to the invasive tumor cells were observed. The strutures of new vessels were incomplete. The capillaries with structural defects were found in carcinoma and adjacent to carcinoma cells. Conclusion:Tumor cells of buccal carcinoma seems to be invasive and able to induce angiogenesis and the angiogenesis ma be favourable for the invasiveness of the carcinoma cells in the early stage of the carcinogenesis.