国产全氟辛烷临床应用的疗效及安全性观察

Clinical efficacy and safety of application of domestic perfluoroetane

目的观察国产全氟辛烷(PFO)临床应用的疗效及安全性。方法随机选取玻璃体切割术中需要应用全氟萘烷的患者30例,应用2.8～5mL国产PFO展平视网膜,然后进行眼内剥膜等操作。观察术中视网膜复位程度、注入和取出的方便性、有无进入视网膜下及对视网膜血管的压迫等情况,随访观察对角膜、晶状体和视网膜的不良反应,以及对屈光介质的影响。采用自身对照的研究方法。结果PFO能在术中很好地展平视网膜,30例患者玻璃体腔PFO均完全取出,无残留。在操作方便性方面评定为合格。术中观察对视网膜血管无明显压迫迹象;术后7d随访观察对角膜、晶状体及视网膜无明显影响。术后7d患者视力:光感者1例,手动/眼前者5例,数指/眼前者14例,0.02～0.05者8例,>0.05～0.1者2例。结论PFO作为视网膜玻璃体切割手术中的辅助工具能很好地展平视网膜,在玻璃体切割手术中应用是安全有效的。

Objective The aim of this study was to evaluate the clinical efficacy and safety of application of domestic perfluoroetane. Methods The clinical data from 30 eases underwent vitrectomy was collected and retrospectively analyzed. A perfluoroetane produced by Shanghai Huajieshi Medical Equipment Corporation was as temponator to expand the retina during the operation and then peeled the epiretinal membrane. The retinal reattaehment degree, the procedure of temponating or removal of the perfluoroetane, the relevant problems such as entering of perfluoroetane into the sub-retlna apace, compression degree of perfluoroetane to retinal vessels were observed. The follow-up study covered toxic and adverse effects of perfluoroetane on cornea, lens and retina as well as the effects on the refraction medium. The volume of perfluoroetane used in intraoperation were 2. 8 - 5 mL in the patients with the average amount 4.29 mL. The written informed consent was obtained from all patients prior to operation. Results Perfluoroetane could expand the retina well during the operation,and all the perfluoroetane was removed thoroughly in all the 30 patients. The operative procedure was qualified and no compression of retinal vessels was seen. No severe adverse responses to cornea,lens and retina were found in intra- and post-operation. Desirable vision was achieved when the patients were discharged after one week in all the patients as follows ：light perception in 1 case, hand movement in 5 cases, counting finger in 14 cases,0.02 - 0.05 in 8 cases, 〉 0.05 - 0.1 in 2 cases. Conclusion The domestic perfluoroetane can expand the retina well. It is effective and safe during vitrectomy.